Evaluating Prognostic Biomarkers for Malignant Pleural Mesothelioma

This study is testing a new way to understand the stage and outlook (prognosis) for people with malignant pleural mesothelioma. Currently, it's hard to know the cancer's stage before surgery or treatment. This research uses tissue samples from your diagnostic biopsy to study specific characteristics with tests like the MPT Test and CLDN15/VIM Test. The goal is to see if these tests can help doctors better classify your cancer stage and predict your prognosis before treatment. We are looking for adults aged 18 or older who have been diagnosed with malignant pleural mesothelioma and are having a diagnostic pleural biopsy, pleuroscopy, or VATS resection. Success for this study means validating a new method for predicting prognosis, measured over 4 years. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 240 participants. It is not specified if it is randomized or blinded.
What's involved
If you join, doctors will collect pleural tissue samples during your routine diagnostic biopsy. This tissue will be stored and studied to test the new method.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of the study is measured at 4 years, which suggests a follow-up period of at least that long.

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NCT03683680

Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers

Recruiting
NAAges 18+InterventionalDiagnostic
Dana-Farber Cancer Institute
~240 participants
Updated 2026-05-05 on ClinicalTrials.gov
What's tested:MPT TestCLDN15/VIM Test

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pre-treatment Prognostic Algorithm Validation
Measured over 4 years
Mesothelioma
1 sites across 1 states
Massachusetts1
  • Raphael Bueno, MD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

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Eligibility criteria

Inclusion

All adult patients with a diagnosis of malignant pleural mesothelioma undergoing
diagnostic pleural biopsy
pleuroscopy
and/or VATS resections
Participants must be 18 years of age or older.

Exclusion

Any patient who is found to be unsuitable for
surgery,
treatment
diagnosis,
  • Pre-treatment Prognostic Algorithm Validation4 years

    The primary objective is to utilize a novel prognostic algorithm to predict the outcome of MPM patients. This algorithm includes 4 different tests: molecular, radiological, and blood based. It will be performed on 240 prospectively-collected samples. A score of 0-4 will be assigned to each patient and the data will be analyzed by a statistician