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Non-invasive Glioma Characterization Through Molecular Imaging

This study is testing a special type of MRI scan called a 3T MRI Scanner using a Mega-laser sequence. This scan helps measure a substance called 2-hydroxyglutarate (2HG) in brain tumors without needing a biopsy. Researchers want to see if this MRI method can accurately measure 2HG in people with suspected or confirmed gliomas (a type of brain tumor) who are already having a biopsy or surgery. The goal is to develop better ways to understand and treat gliomas. The study is open to adults aged 18 and older who can have an MRI and are having a brain lesion biopsy or removal. The current recruitment status is unclear.

Study design
This is an interventional pilot study planning to enroll 30 participants. It aims to develop and optimize MRI-based sequences.
What's involved
You would undergo a 3T MRI scan. Your 2HG concentration will be measured from the MRI and from tissue samples taken on Day 1.
Compensation
Not stated in the trial record.
Follow-up
Measurements for 2HG concentration are taken on Day 1 from both the MRI and tissue samples. Further follow-up is not specified.

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NCT03684109

Non-invasive Glioma Characterization Through Molecular Imaging

Recruiting
NAAges 18+InterventionalDiagnostic
University of Miami
~30 participants
Updated 2026-04-20 on ClinicalTrials.gov
What's tested:3T MRI Scanner

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
2HG Concentration via 3T MRI Scanner
Measured over Day 1
+1 more outcome measured

Conditions

Glioma
Brain Tumor
Primary Brain Tumor
Malignant Glioma
Malignant Primary Brain Tumor

Explore related trials

Glioma

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Macarena De La Fuente, MD · PRINCIPAL_INVESTIGATOR · University of Miami

Who to contact

Nathalie Padron
[email protected]
305-243-3530
Email the study team

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Eligibility criteria

Inclusion

Adults (≥18 year old)
Subjects with suspected or confirmed gliomas and who will have a medically indicated biopsy or resection of his/her brain lesion.

Exclusion

Adults unable to consent
Individuals who are not yet adults (infants, children, teenagers)
Pregnant women
Patients unable to have MRI done

What this trial measures

  • 2HG Concentration via 3T MRI ScannerDay 1

    2HG concentrations as measured via 3T MRI Scanner.

  • 2HG Concentration from tissue samplesDay 1

    2HG concentrations as measured via patient's surgically excised tissue sample ex vivo by tissue based liquid chromatography-mass spectrometry (LC-MS)