This observational study from Georgetown University is looking at ways to better diagnose Alzheimer's disease, mild cognitive impairment (a stage between normal aging and dementia), and other brain diseases before death. Researchers are collecting information about biology, lifestyle, and thinking abilities over time. They want to see if different tests, like those using blood or spinal fluid, genetic testing, and cognitive (thinking) assessments, can help with early diagnosis. You can join if you are 45 or older. If you are between 45 and 50, you need to have a close family member with a neurodegenerative disease. The main goal is to see how well these tests work over 9 years, as measured by a scale called the Clinical Dementia Rating (CDR). The study status is currently unclear.

Study design

This is an observational study with a planned enrollment of 1000 participants. It is not testing a specific drug or intervention.

What's involved

You can choose to have a single visit or participate in ongoing visits. Visits involve recording demographic and medical information, brief cognitive testing, and collecting blood and/or spinal fluid samples.

Compensation

Not stated in the trial record.

Follow-up

Participants in the longitudinal substudy will have ongoing visits, and the primary endpoint is measured at 9 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.