Registry for Adults With Plasma Cell Disorders

This study is creating a registry (a collection of information) for adults with plasma cell disorders (PCDs), which include conditions like multiple myeloma, amyloidosis, and Castleman's disease. The main goal is to gather information about these conditions and how patients are assessed over 10 years. You may be eligible if you are an adult patient with a diagnosed PCD and are receiving care at UNC Cancer Hospitals or affiliated clinics. While there are no specific interventions (treatments) being tested, the study involves completing an assessment at the start and over time, which looks at your functional status, medical conditions, and well-being. There's also an optional blood draw to look at a genetic marker related to aging. This information will help support future research into PCDs.

Study design
This is an observational study aiming to enroll 2000 participants to create a registry of patients with plasma cell disorders.
What's involved
You would complete an assessment at the beginning of the study and then periodically over time. This assessment covers various aspects of your health and well-being, and your medical records will also be reviewed.
Compensation
Not stated in the trial record.
Follow-up
The primary goals of the study are measured over 10 years, indicating a long-term follow-up period.

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NCT03717844

Registry for Adults With Plasma Cell Disorders (PCD's)

Recruiting
Not specifiedAges 18+Observational
UNC Lineberger Comprehensive Cancer Center
~2,000 participants
Updated 2025-11-20 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Creation of a Registry of Plasma Cell Disorder (PCD) patients
Measured over 10 years
+1 more outcome measured
Multiple Myeloma
Amyloidosis
Cryoglobulinemia
Castleman's Disease
Light Chain Deposition Disease
Heavy Chain Deposition Disease
Polyneuropathy Organomegaly Endocrinopathy Monoclonal Gammopathy and Skin Changes
Smoldering Multiple Myeloma
Plasma Cell Leukemia
1 sites across 1 states
North Carolina1
  • Sascha Tuchman, MD · PRINCIPAL_INVESTIGATOR · UNC Lineberger Comprehensive Cancer Center

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Eligibility criteria

Inclusion

Patients have an outpatient appointment or are hospitalized inpatient at UNC Cancer Hospitals, or affiliated clinic settings or participating sites for the evaluation and management of a PCD.
Patients have a documented diagnosis of PCD defined as the presence of a monoclonal protein and/or monoclonal plasma cell population. Examples of PCDs include but are not limited to monoclonal gammopathy of uncertain significance; smoldering myeloma; multiple (active) myeloma; plasma cell leukemia; Castleman's disease; amyloidosis; light and/or heavy chain deposition disease; Polyneuropathy, Organomegaly, Endocrinopathy,Monoclonal gammopathy and Skin changes (POEMS) syndrome; and cryoglobulinemia.
Age ≥18 years.
Must consent to participation in this study and agree to complete the assessment at baseline and follow-up time points.
Must be able to read and speak English.

Exclusion

Physical or psychiatric/behavioral illnesses or problems that the treating clinician feels would preclude successful participation in the study.
There are no imaging or lab studies required to determine eligibility.
  • Creation of a Registry of Plasma Cell Disorder (PCD) patients10 years
  • Completion of baseline and longitudinal assessments in PCD patients10 years