Liposomal Bupivacaine vs. Plain Bupivacaine for Post-Surgery Pain
This study is looking at how two different pain medications, Exparel (liposomal bupivacaine) and plain bupivacaine, work in your body after certain lung surgeries (thoracoscopy). Researchers want to see if Exparel, which is designed to release slowly, can provide good pain relief without causing too much of the drug to enter your bloodstream. They will compare the levels of bupivacaine in your blood after you receive either Exparel or plain bupivacaine through injections around your ribs (intercostal injections). The goal is to make sure the drug levels stay safe while still managing your pain effectively. This study is for adults over 18 who are having specific minimally invasive lung surgeries.
- Study design
- This interventional study plans to enroll 40 participants. It compares two different drug interventions: Exparel and Bupivacaine.
- What's involved
- You would receive intercostal injections of either Exparel or Bupivacaine during your surgery. Your blood will be tested at several time points after surgery, up to 72 hours.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your blood will be monitored for bupivacaine levels for up to 72 hours after your injections.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Zoulfira Nisnevitch-Savarese, MD · PRINCIPAL_INVESTIGATOR · Penn State Hershey College of Medicine
Who to contact
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What this trial measures
- Plasma concentration of bupivacaine0.5, 1, 2, 4, 8, 12, 24, 32, 48, 72 hours after intraoperative multiple level intercostal injections.
The primary end points to be measured in the study are plasma concentrations of bupivacaine 0.5, 1, 2, 4, 8, 12, 24, 32, 48 hours after intraoperative multiple level intercostal injections of plain Bupivacaine or Exparel. If the patient remains in the hospital, additional samples will be collected at 72 hours. If the patient gets discharged before this time, the last sample will be drawn at time of discharge from the hospital.