SEACOAST 1: Sedation with Collateral Support in Endovascular Therapy for Acute Ischemic Stroke
This study, called SEACOAST 1, is looking at different ways to give general anesthesia (GA) to people having a procedure for an acute stroke. Researchers want to see if controlling carbon dioxide (CO2) levels during GA can improve blood flow to the brain and lead to better recovery. You might be able to join if you are 18 to 110 years old, have had a recent acute stroke, and meet certain criteria for stroke severity and brain imaging. The study compares two types of GA: one with normal CO2 levels (normocarbia) and one with slightly higher CO2 levels (mild hypercarbia). The main goal is to see which method helps blood vessels around the stroke area (collateral circulation) work better, measured right before the procedure. This study plans to enroll 90 participants.
- Study design
- This is a randomized, blinded study comparing two types of general anesthesia in about 90 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary outcome is measured immediately prior to revascularization.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke
At a glance
Conditions
NCT03737786
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
UCLA Stroke Center
Los Angeles, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Radoslav Raychev, MD · PRINCIPAL_INVESTIGATOR · University of California, Los Angeles
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Modified Angiographic collateral circulation assessed by blinded core labImmediately prior to revascularization
Modified American Society of Interventional and Therapeutic Neuroradiology (ASITN) grading scale is an ordinal 0-4 scale for angiographic collateral assessment. It runs from 0 (no collaterals) to 4 (excellent collaterals) as follows: 0: No visible collaterals to the ischemic site; 1: Slow collaterals to the periphery of the ischemic site with persistence of some defect; 2 (-): rapid collaterals to the periphery of the ischemic site with collateral filling in \<50% of the territory; 2 (+): rapid collaterals to the periphery of the ischemic site with collateral filling \> 50% of the territory; 3: Collaterals with slow but complete angiographic blood flow of the ischemic bed by the venous phase; 4: Complete and rapid collateral blood flow to the vascular bed in the entire ischemic territory by retrograde perfusion.