Back to search results
NCT03741023

Disorders of the Acute Phase Response Following Trauma and Invasive Surgery

Enrolling by Invitation
NAAges 2+InterventionalBasic science
Vanderbilt University Medical Center
~320 participants
Updated 2026-03-27 on ClinicalTrials.gov
What's tested:Blood draw (venipuncture or fingerstick)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Interleukin-6 (IL-6)
Measured over During hospitalization (approximately 7-21 days)
+2 more outcomes measured

Conditions

Acute Phase Response

Explore related trials

Acute-Phase Reaction

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • Jonathan Schoenecker, MD, PhD · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Any patient admitted to or treated in the VUMC Adult Trauma Unit
Patients ages 16 and older (all included in the adult trauma unit admissions)
Patients will be divided into sub-groups for analyses based on type of trauma (TBI, blunt force trauma, polytrauma, etc) and severity (Level 1 vs non-level 1 trauma)
Any patient admitted for an invasive elective surgery associated with high blood loss or a high risk of vascular complications at VUMC/VCH. Enrollment will be at the discretion of the attending physician
This may include, but is not limited to, orthopedic and vascular surgery patients
Volunteers should be male or female
Age 18-70 years of age
Weight greater than 110lbs

Exclusion

None
Chronic medical conditions such as: diabetes, hypertension, high cholesterol, rheumatologic disorders, infections, etc.
No history of recent traumatic injury (within the past year)
Pregnant females or people on hormone replacement therapy
People on any anticoagulant medication or NSAIDS

What this trial measures

  • Interleukin-6 (IL-6)During hospitalization (approximately 7-21 days)

    A change in Interleukin-6 (IL-6) lab value following traumatic injuries or traumatic elective surgeries will be used to determine change in systematic inflammation.

  • Thrombin-Antithrombin (TAT) ComplexDuring hospitalization (approximately 7-21 days)

    A change in the Thrombin-antithrombin (TAT) complex following traumatic injuries or traumatic elective surgeries will be used to determine change in coagulation.

  • D-DimerDuring hospitalization (approximately 7-21 days)

    A change in d-dimer lab value following traumatic injuries or traumatic elective surgeries will be used to determine change in fibrinolysis.