Cardiovascular Disease Risk in Women with Endometriosis

This study is looking into how endometriosis and its treatments might affect your heart health. Researchers want to understand if suppressing estrogen, a common treatment for endometriosis, could impact blood vessel function. They will be testing a medication called Elagolix (400 mg/day oral, 2X200 mg tablets/day for 4 days) to see its effects. The study aims to measure changes in blood vessel function using tests like Flow Mediated Vasodilation and Microvascular skin blood flow analysis. You may be able to join if you are a woman between 18 and 45 years old, with or without endometriosis. The study is looking for 40 participants in total. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 40 women between 18 and 45 years old, both with and without endometriosis.
What's involved
Participants will receive Elagolix for 4 days. Blood vessel function will be measured at 2 minutes and 15 minutes during the study.
Compensation
Not stated in the trial record.
Follow-up
Blood vessel function will be measured at 2 minutes and 15 minutes after certain procedures.

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NCT03746535

Cardiovascular Disease Risk in Women With Endometriosis

Recruiting
EARLY_PHASE1Ages 18–45InterventionalTreatment
Yale University
~40 participants
Updated 2025-05-23 on ClinicalTrials.gov
What's tested:Elagolix

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Flow Mediated Vasodilation Microvascular skin blood flow analysis
Measured over 2 minutes
+1 more outcome measured
Endometriosis
1 sites across 1 states
Connecticut1
  • Nina Stachenfeld, MD · PRINCIPAL_INVESTIGATOR · Yale University

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Eligibility criteria

Inclusion

Young women between the ages of 18 and 45 years (Controls);
Young women between the ages of 18 and 45 years with endometriosis.

Exclusion

Subjects who smoke
Subjects who have diabetes,
Subjects with sleep apnea or BP\>140/90 will be excluded.
Women with endometriosis and severe acute pain requiring immediate treatment will be excluded.
  • Flow Mediated Vasodilation Microvascular skin blood flow analysis2 minutes

    Blood flow velocity will be measured using the Sonoscope S2 ultrasound imaging system.

  • Microdialysis perfusions15 minutes

    Following recovery from the microdialysis probe insertions we will measure resting skin blood flow (SkBF).