Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service

This study is comparing two different methods of pain control for total knee replacement surgery in adults aged 18 to 65. Both methods involve a combination of pain relief techniques, but they differ in how one specific pain block, called an adductor canal block (ACB), is delivered. One group will receive a single shot of the ACB, while the other will receive a continuous adductor canal catheter (ACC) which delivers pain medicine over time. Researchers want to see which method leads to less opioid pain medication use in the first 24-48 hours after surgery. You may be eligible if you have osteoarthritis, are scheduled for a total knee replacement, speak English, live within an hour of the hospital, and have a smartphone. The study's current status is unclear.

Study design
This is an interventional study where 94 participants will be randomly assigned to one of two groups to compare different pain management techniques.
What's involved
You would receive either a single-shot adductor canal block or a continuous adductor canal catheter as part of your pain management during and after total knee replacement surgery.
Compensation
Not stated in the trial record.
Follow-up
Your opioid consumption will be measured for 24-48 hours after your spinal anesthesia.

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NCT03747146

Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service

Recruiting
NAAges 18–65InterventionalTreatment
Hospital for Special Surgery, New York
~94 participants
Updated 2026-04-28 on ClinicalTrials.gov
What's tested:Continuous Adductor Canal Catheter (ACC)Adductor Canal block with sham catheter

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Opioid consumption during 24-48 hour period
Measured over Post-operative day 1-2 (24-48 hours post spinal induction)
Anesthesia
1 sites across 1 states
New York1
  • David Kim, MD · PRINCIPAL_INVESTIGATOR · Hospital for Special Surgery, New York

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Eligibility criteria

Inclusion

Patients with osteoarthritis scheduled for a primary total knee arthroplasty with a participating surgeon
Planned use of regional anesthesia
Ability to follow study protocol
English speaking (secondary outcomes include questionnaires validated in English only)
Lives within one hour of the hospital
Has a smart phone

Exclusion

Hepatic or renal insufficiency
Younger than 18 years old or older than 65 years ol
Patients undergoing general anesthesia
Allergy or intolerance to one of the study medications
BMI \>40
Diabetes
American Society of Anesthesiologists (ASA) status III or IV
Chronic gabapentin/pregabalin use (regular use for longer than 3 months)
Patients with chronic pain (from a referral to chronic pain service) or a pain catastrophizing scale (PCS \>30)
Patients with severe valgus deformity or flexion contracture
Patients unable to follow home catheter instructions and unwilling to go home with an infusing catheter
Patients who have no home caregivers in the event that a catheter is to be sent home with the patient
Patients with planned stay at rehab facility (to avoid medical device being tampered with at the rehab facility)
Non-English speakers (secondary outcomes include questionnaires validated in English only)
  • Opioid consumption during 24-48 hour periodPost-operative day 1-2 (24-48 hours post spinal induction)

    Patients will be asked to report their opioid consumption during the 24-48 hour time period after spinal induction. This data will be converted to morphine milligram equivalents (mme).