Collagen Cross-linking for Keratoconus

This study is looking at a procedure called Laser Custom Corneal Collagen Cross-Linking (CXL) for people with keratoconus (a condition where the clear front part of the eye, the cornea, thins and bulges). Researchers will use special measurements from an OCT (Optical Coherence Tomography) device to guide the laser settings during the CXL procedure. The goal is to see if this approach improves your best vision with glasses or contacts. To join, you need to be at least 18 years old, have keratoconus, and a minimum corneal thickness of 410 microns. The study is currently unclear on its recruitment status and plans to enroll 100 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 100 participants.
What's involved
You would need to be able to maintain a steady gaze for OCT imaging and commit to all required study visits.
Compensation
Not stated in the trial record.
Follow-up
Your vision will be checked at 6 months after the CXL procedure to see the improvement.

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NCT03760432

Collagen Cross-linking in Keratoconus

Recruiting
NAAges 18+InterventionalTreatment
Oregon Health and Science University
~100 participants
Updated 2025-09-09 on ClinicalTrials.gov
What's tested:Laser Custom Corneal Collagen Cross-Linking

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Improvement in best spectacle-corrected visual acuity after laser custom CXL
Measured over 6 months after the CXL procedure
Keratoconus
1 sites across 1 states
Oregon1
  • David Huang, MD, PhD · PRINCIPAL_INVESTIGATOR · Oregon Health and Science University

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Eligibility criteria

Inclusion

Diagnosis of keratoconus
Minimum corneal thickness of 410 microns

Exclusion

Inability to maintain fixation for OCT imaging
Inability to commit to required study visits
Inability to give informed consent
Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery
Mature cataracts if found to limit visual potential to worse than 20/40
  • Improvement in best spectacle-corrected visual acuity after laser custom CXL6 months after the CXL procedure

    The primary goal of the trial is to determine the extent of visual improvement after laser custom CXL compared to preoperative measurements. Vision will be checked at various time points, but the primary time point will be 6-months post-procedure.