This study is looking at how pre-diabetes and type 2 diabetes affect muscle loss (atrophy) and recovery after a period of bed rest in older adults. You would participate in 10 days of bed rest, followed by 4 weeks of recovery where you can move around. Researchers will measure your leg lean mass and mitochondrial respiration (how your cells make energy) before and after bed rest, and again after the recovery period. The goal is to understand why older adults with diabetes lose muscle faster and how they recover. To join, you must be between 60 and 80 years old, have pre-diabetes or type 2 diabetes, and be taking certain medications like DPP-4 inhibitors, Sulfonylureas, and/or Metformin, with an A1C (a measure of blood sugar) below 8.0. The current recruitment status is unclear.

Study design

This is an interventional study with 50 planned participants. It involves a period of bed rest followed by recovery.

What's involved

You would remain in bed rest for 10 complete days, followed by 4 weeks of ambulatory recovery. Muscle biopsies will be collected during bed rest.

Compensation

Not stated in the trial record.

Follow-up

Your leg lean mass will be measured following 4 weeks of ambulatory recovery after bed rest.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.