Measuring Analgesic Interventions in Children and Teens

This study aims to find a better way to measure pain and how well pain medications (analgesics) are working, especially in children and those who can't easily express their pain. Researchers will observe how a person's pupil (the black center of the eye) reacts to light over several hours after receiving pain relief. This reaction, called Pupillary Reflex Dilation (PRD), will be measured at specific times (0, 15, 30, 45, 60, 90, 120, and 180 minutes) to see if it can be a reliable way to understand pain and the effectiveness of treatment. You can join if you are between 7 and 21 years old, are receiving pain treatment at Children's National Medical Center Pain Clinic, and do not have an eye condition that would affect pupil measurements. The study plans to include 120 participants.

Study design
This is an observational study, meaning researchers will watch and collect information without providing new treatments. It plans to include 120 participants.
What's involved
You would have your pupil reactions measured at several time points (0, 15, 30, 45, 60, 90, 120, and 180 minutes) after receiving pain medication.
Compensation
Not stated in the trial record.
Follow-up
Pupillary Reflex Dilation (PRD) will be measured for up to 180 minutes (3 hours).

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NCT03794362

Measuring Analgesic Interventions

Recruiting
Not specifiedAges 7–21Observational
Julia Finkel
~120 participants
Updated 2026-04-07 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pupillary Reflex Dilation (PRD) Area under Curve (AUC)
Measured over 0, 15, 30, 45, 60, 90, 120, 180 minutes
Pain
1 sites across 1 states
District of Columbia1
  • Julia C Finkel, MD · PRINCIPAL_INVESTIGATOR · Children's National Research Institute

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  • Pupillary Reflex Dilation (PRD) Area under Curve (AUC)0, 15, 30, 45, 60, 90, 120, 180 minutes

    The changes that occur in PRD AUC as a response to an analgesic intervention will be investigated. The differences are calculated by comparing the parameters from before the intervention to after the intervention.