Understanding Vascular Changes in Preeclampsia
This observational study, NCT03806283, is looking into how blood vessels change during pregnancy, especially in women with pre-eclampsia (a serious pregnancy complication characterized by high blood pressure). Researchers will collect small tissue samples from the omentum (a fatty tissue in the abdomen) and the placenta during a planned or unplanned C-section. They will study these samples to understand the role of a specific receptor, AT2R, in blood vessel function. The goal is to see if treatments that target AT2R could help improve blood vessel health in pre-eclampsia. You may be able to join if you are a woman between 18 and 40 years old, are between 28 and 41 weeks pregnant with one baby, and are having a C-section. The study aims to enroll up to 166 participants.
- Study design
- This is an observational study comparing pregnant women with and without pre-eclampsia. It plans to enroll up to 166 participants.
- What's involved
- If you participate, tissue samples will be collected from your omentum and placenta during your C-section. Your medical records will also be reviewed.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study's main goals will be measured at 1 year, but it's not specified if this involves participant follow-up.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Mechanisms of Pregnancy Vascular Adaptations
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Sathish Kumar, PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Quantify the vascular AT2R expression and vascular function in placental and omental vascular arteries in both preeclamptic and controlled pregnancies.1 year
The researchers will measure the amount and distribution of vascular angiotensin II type 1 receptor (AT1R) and AT2R during normal human pregnancy and in preeclampsia. The researchers will assess if AT2R expression varies with severity of preeclampsia. Based on pilot data, the researchers expect decreased AT2R and increased AT1R protein levels in preeclamptic vs normotensive vessels.
- To test if ex-vivo treatment of AT2R agonists reverses the endothelial dysfunction and improves vasoconstriction in the preeclamptic vessels.1 year
The researchers will quantify vascular AT2R expression and vascular function in placental and omental arteries of preeclamptic vs normal pregnant women. Vascular function studies will also test if ex vivo treatment with AT2R agonist reverses endothelial dysfunction and vasoconstriction in preeclamptic vessels.
- To test AT2R mediated mechanisms on endothelial derived hyperpolarizing factor, nitric oxide and prostacyclin pathway of vascular relaxation to examine AT2's role in vaso-relaxation and AT2R mediated vasoconstrictor pathway will be defined.1 year
To test the AT2R-mediated mechanisms, endothelium-derived hyperpolarizing factor (EDHF), nitric oxide, and prostacyclin (PGI2) pathways of vascular relaxation and AT1R-mediated vasoconstrictor pathways will be determined. Also, the expression of endothelial nitric oxide synthase, its activity state, and signaling components of EDHF and PGI2 pathways, as well as nitrate/nitrite and PGI2 production and changes in membrane potential, will be measured