Understanding Insulin Resistance with Intralipid and Palm Oil
This study aims to understand how different types of fats affect insulin resistance in muscles. Researchers will give participants either Intralipid or Palm Oil Emulsion through a tube into their small intestine overnight. On a separate day, you will also receive a saline (saltwater) infusion as a comparison. The main goal is to see how these fats change specific signaling molecules in muscle cells before and after a special test that measures how your body uses insulin (euglycemic, hyperinsulinemic clamp). This study is for healthy men and premenopausal women aged 18-55 with a BMI between 18-27. The study is currently unclear on its recruitment status and plans to enroll 60 participants.
- Study design
- This interventional study plans to enroll 60 participants. Each participant will receive Intralipid, Palm Oil Emulsion, and saline on separate days to compare their effects.
- What's involved
- Participants will receive overnight infusions of Intralipid, Palm Oil Emulsion, and saline through a tube into their small intestine. Measurements will be taken before and after a euglycemic, hyperinsulinemic clamp.
- Compensation
- Not stated in the trial record.
- Follow-up
- Changes in fatty acid enrichment will be measured at 18 hours after the euglycemic, hyperinsulinemic clamp.
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Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Michael D Jensen, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
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Do you actually qualify for this trial?
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Inclusion
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What this trial measures
- Change in fatty acid enrichment of intramyocellular signaling molecules before and after a euglycemic, hyperinsulinemic clamp18 hours
The study involves the use of a hyperinsulinemic, euglycemic clamp to compare fatty acid enrichments in intramyocellular signaling molecules. The first half of the study will be the "pre-clamp" stage. During this stage, volunteers will receive an intravenous infusion of C13-labelled palmitate as a tracer in order for enrichment calculations to be performed pre-clamp. One muscle biopsy will be obtained to measure fatty acid enrichment within intramyocellular ceramides, diacylglycerols, long-chain acylcarnitines, and intramyocellular triglycerides. The insulin clamp will then commence, and volunteers will simultaneously receive an intravenous infusion of a second tracer, D-9 palmitate. This tracer will allow us to calculate enrichments during the insulin clamp stage of the study. A second muscle biopsy will be performed at the end of the insulin clamp, and similar enrichment calculations will be performed.