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Nicotinamide Riboside for Blood Pressure and Arterial Stiffness

This study is looking at whether Nicotinamide riboside, a dietary supplement, can help lower high blood pressure and reduce arterial stiffness in middle-aged and older adults. You might be able to join if you are between 50 and 79 years old, have systolic blood pressure (the top number) between 120 and 159 mmHg, and a body mass index (BMI) under 40. The main goal is to see if Nicotinamide riboside lowers systolic blood pressure after 3 months. This study is currently unclear about its recruitment status and plans to enroll 118 participants.

Study design
This is a randomized, double-blind, placebo-controlled study, meaning participants are randomly assigned to receive either Nicotinamide riboside or a placebo, and neither you nor the researchers will know which you are receiving. It is a single-site study.
What's involved
Participants will take study pills twice a day for 3 months. Your systolic blood pressure will be measured at the 3-month mark.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, systolic blood pressure, is measured at 3 months, indicating the duration of the main observation period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03821623

Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

Recruiting
PHASE2Ages 50+InterventionalTreatment
Douglas Seals
~118 participants
Updated 2025-02-21 on ClinicalTrials.gov
What's tested:Nicotinamide ribosidePlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Systolic blood pressure
Measured over 3 months

Conditions

Hypertension
Aging

Explore related trials

Hypertension

Where it's being run

1 sites across 1 states
Colorado1

Who to contact

Daniel H Craighead, PhD
[email protected]
303-492-7702
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Ability to provide informed consent
Willing to accept random assignment to condition
Systolic blood pressure between 120 and 159 mmHg
Body mass index \<40 kg/m2
Weight stable in the prior 3 months (\<2 kg weight change) and willing to remain weight stable throughout the study
Absence of other clinical disease as determined by medical history, physical examination, blood chemistries, ankle-brachial index, and 12-lead ECG at rest and during graded treadmill exercise
Ankle-brachial index \>0.7
Total cholesterol \<240 mg/dL
Fasting plasma glucose \<126 mg/dL
Normal 12-lead ECG at rest and during graded treadmill exercise to fatigue

Exclusion

Systolic blood pressure \<120 or \>/= 160 mmHg
Currently taking antihypertensive medications
Other chronic medical condition (e.g., diabetes, chronic kidney disease, cancer)
Current smoker
Alcohol dependence or abuse
Uncontrolled thyroid disease or change in thyroid medication within previous 3 months
Abnormal blood pressure response to exercise (drop in SBP below resting pressure or SBP \>160 mmHg or DBP \>115 mmHg)
Regular vigorous aerobic/endurance exercise (\>4 bouts/weeks, \>30 min/bout at a workload \>6 METS)

What this trial measures

  • Systolic blood pressure3 months

    Resting systolic blood pressure