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Walnuts for Prostate Cancer Progression

This study, called WALNUTS for POWER, is testing if eating walnuts daily can affect prostate cancer progression. It involves 50 men who have been diagnosed with prostate cancer and are planning to have surgery (radical prostatectomy or RP). You would either continue your usual diet or add 2 ounces of walnuts daily for 4-10 weeks. The study will look at changes in a marker called Ki67 in your prostate tissue after surgery to see if the walnuts had an effect. The current status of this study is unclear.

Study design
This is a randomized study involving 50 men. Participants will be randomly assigned to one of two groups: a usual diet group or a group that adds walnuts to their usual diet.
What's involved
You would have a baseline visit after your biopsy and before surgery. The intervention period, where you would eat walnuts or your usual diet, would last 4-10 weeks, ending with a final visit before your surgery.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at 10 weeks, which is when the prostate tissue is examined after surgery.

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NCT03824652

WALNUTS for POWER: Polyphenols, Omega-3 Fatty Acids, Weight Loss, and EneRgy

Recruiting
PHASE2Ages 18+InterventionalTreatment
Stephen Freedland
~50 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:walnutsusual dietphone counseling with dietitian

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean difference in prostatic tissue Ki67 expression from baseline biopsy to RP
Measured over 10 weeks

Conditions

Prostate Cancer

Explore related trials

Prostate Carcinoma

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Stephen Freedland, MD · PRINCIPAL_INVESTIGATOR · Cedars-Sinai Medical Center

Who to contact

Clinical Trials Navigator
[email protected]
310-423-5842
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Pathologically confirmed prostate adenocarcinoma.
Diagnostic biopsy cores with ≥10 cores with each core examined separately to determine exact tumor location.
Biopsy grade group 2 or higher (Gleason ≥7).
Planning to undergo RP.
Willing to adhere to a usual diet with the possible addition of 2 oz of walnuts per day.
Reads, writes, and understands English.
Age 18 or older

Exclusion

Allergy to nuts.
History of receiving hormone therapy or antiandrogen therapy.
Use of 5-alpha reductase inhibitors in the past 6 months.
Prior prostate radiotherapy (external beam or brachytherapy) or prior prostate cryotherapy.
Currently enrolled in a modified diet/weight loss program and/or taking dietary supplements that contain omega-3s (e.g., fish oil).
Other active malignancy, excluding basal cell carcinoma or squamous cell carcinoma
Significant co-morbidities (e.g., cardiac, pulmonary, liver disease, alcohol/drug addiction, malabsorption syndromes), that in the opinion of the study physician make the patient ineligible.
Individuals with psychological/mental conditions which can affect the consent process and/or their adherence to the protocol.

What this trial measures

  • Mean difference in prostatic tissue Ki67 expression from baseline biopsy to RP10 weeks