Auricular Transcutaneous Electrical Nerve Stimulation for Autism

This study is looking at how a treatment called auricular transcutaneous electrical nerve stimulation (tVNS) affects adults with high-functioning autism. tVNS uses a mild electrical current applied to specific points on the ear. Participants will be randomly assigned to receive tVNS at either 1 Hz or 20 Hz for 30 minutes a day, up to five times a week, for three weeks. Researchers will measure changes in autism symptoms using a tool called the Autism Treatment Evaluation Checklist (ATEC) at the beginning and end of the treatment period. You may be able to join if you are 18-60 years old, have a diagnosis of high-functioning autism, and do not show aggressive behaviors. The current status of this study is unclear.

Study design
This is an interventional study where participants are randomly assigned to one of two treatment groups. The study plans to enroll 40 high-functioning adults with autism.
What's involved
You would receive auricular transcutaneous electrical nerve stimulation for 30 minutes a day, up to five times a week, for three weeks. Your autism symptoms will be measured at the start and end of this period.
Compensation
Not stated in the trial record.
Follow-up
Your autism symptoms will be measured after the 3-week treatment period.

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NCT03827941

Auricular Transcutaneous Electrical Nerve Stimulation Treatment of Autism

Recruiting
NAAges 18–60InterventionalTreatment
Massachusetts General Hospital
~40 participants
Updated 2026-07-17 on ClinicalTrials.gov
What's tested:1 Hz Auricular transcutaneous electrical nerve stimulation20 Hz Auricular transcutaneous electrical nerve stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Autism Treatment Evaluation Checklist (ATEC)
Measured over Baseline and after 3-week treatment
Autism Spectrum Disorder

NCT03827941

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • MGB

    Charlestown, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Jian Kong · PRINCIPAL_INVESTIGATOR · MGH

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  • Change in Autism Treatment Evaluation Checklist (ATEC)Baseline and after 3-week treatment

    ATEC will be reported by investigator in a total and for each of the 4 subscales as follows: (1) speech/language/communication subscale; (2) social subscale; (3) sensory and cognitive awareness subscale; and (4) health / physical / behavior problem subscale. The total score ranges from 0 to 179; a higher score indicated worsening while a lower score indicated improvement.