Detecting Unsuspected Small Airways Obstruction in Cystic Fibrosis
This observational study aims to find out if children and adults with cystic fibrosis (CF) have small airways obstruction even when their routine lung function tests (spirometry) appear normal. Researchers will use spirometry and lung CT scans to look for this "unsuspected" obstruction. You may be able to join if you are between 5 and 40 years old, have cystic fibrosis, and your routine spirometry results (FEV1, FVC, and FEV1/FVC%) are within the normal range. The study's success will be measured by its ability to detect this unsuspected small airway obstruction over a 5-year period. The current status of this study is unclear.
- Study design
- This is an observational study with a planned enrollment of 100 participants. It is not a randomized or blinded study.
- What's involved
- Participants will undergo spirometry (a breathing test) and lung CT scans. The duration of participation is not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint for detecting unsuspected small airway obstruction is measured at 5 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Detection of Unsuspected Small Airways Obstruction in Cystic Fibrosis
At a glance
Conditions
Where it's being run
2 sites across 1 statesStudy leadership
- Arthur Gelb, MD · PRINCIPAL_INVESTIGATOR · University of California, Los Angeles
Who to contact
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What this trial measures
- Detection of Unsuspected Small Airway Obstruction in Cystic Fibrosis5 years
Retrospective analysis of pre bronchodilator spirometry, and lung CT study to detect abnormal FEF75% in the presence of normal spirometry and FEF25-75. Detect isolated abnormal pre bronchodilator spirometry at 75%FVC