Preventing Alzheimer's With Cognitive Training

This study is looking at whether computerized cognitive training can help prevent mild cognitive impairment (a stage between normal aging and dementia) or dementia, including Alzheimer's disease. Researchers want to see if completing 45 sessions of either "Cognitive Training" or "Computerized Cognitive Stimulation" can reduce the chances of developing these conditions. You might be able to join if you are 65 or older, can speak English or Spanish, and have good enough sight, hearing, and motor skills to use a computer. The main goal is to see how many people develop mild cognitive impairment or dementia over three years. The study is currently unclear on its recruitment status but plans to enroll 7600 participants.

Study design: This is a randomized clinical trial that plans to include 7600 adults aged 65 and older. Participants will be assigned by chance to one of the two cognitive training groups.
What's involved: Participants will complete a total of 45 computerized sessions. They will also undergo screening questionnaires, brief memory and depression screenings, and other questionnaires.
Compensation: Not stated in the trial record.
Follow-up: The primary outcome, incidence of mild cognitive impairment or dementia, will be measured at three years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Preventing Alzheimer's With Cognitive Training

Active, Not Recruiting

PHASE3Ages 65+InterventionalPrevention

University of South Florida

~7,600 participants

Updated 2026-08-24 on ClinicalTrials.gov

What's tested:Cognitive TrainingComputerized Cognitive Stimulation

At a glance

Recruiting sites

0 of 7 listed sites are recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Incidence of mild cognitive impairment or dementia

Measured over Three years

Conditions

Age-related Cognitive Decline

Alzheimer's Disease and Related Dementias

Where it's being run

7 sites across 3 states

Florida5

North Carolina1

South Carolina1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime

Eligibility criteria

Inclusion

Be age 65 or older at time of consent

Have ability to speak and understand English or Spanish

Report adequate sensorimotor capacity to perform the computer exercises

Report adequate visual capacity to read from a computer screen at a typical viewing distance

Show adequate auditory capacity to understand conversational speech

Show adequate motor capacity to touch a computer screen or control a computer mouse.

Have no evidence of Mild Cognitive Impairment (MCI) or dementia, as assessed by the Montreal Cognitive Assessment score \>=26.

Have adequate mental health (no self-reported diagnoses of mental illness that would interfere with ability to comply with study procedures or benefit from intervention)

Wiling to complete all study activities

Ability to understand study procedures and comply with them for the length of the study

Exclusion

Currently enrolled in another randomized clinical trial, treatment trial, or another research study that assesses cognition

Previous participation in a cognitive training study

Self-reported vision, hearing, or motor difficulties that would interfere with the ability to complete the study interventions

Self-reported diagnosis of mild cognitive impairment, dementia, stroke, traumatic brain injury, brain tumor, or a neurological disorder that affects cognition or would interfere with the ability to benefit from the study intervention (e.g., Parkinson disease, multiple sclerosis), or any other unstable medical conditions that is predisposing to imminent cognitive or functional decline (e.g., congestive heart failure, chronic obstructive pulmonary disorder dependent on oxygen, or undergoing chemotherapy or radiation).

Self-reported use of medications typically prescribed for dementia such as: Namenda, Memantine, Namzaric, Donepezil, Aricept, Rivastigmine, Exelon, Razadyne, Galantamine, Reminyl, aducanumab, Aduhlem.

Completion of 10 or more hours of a computerized cognitive training program in the last 5 years such as: Lumosity, Posit Science Brain Fitness, InSight, or Brain HQ, Lace, CogMed, CogniFit, Happy Neuron, Elevate, or Dakim

Severe depressive symptoms (Geriatric Depression Scale score \>=5)

What this trial measures

Incidence of mild cognitive impairment or dementiaThree years
clinical diagnosis of mild cognitive impairment or dementia

Trialytics