Pain Management After Knee Arthroscopic Surgery

This study is looking at different ways to manage pain after knee arthroscopic surgery (a type of knee surgery using small cuts and a camera). We want to see if common non-opioid medications like Ibuprofen and Acetaminophen work as well as the opioid medication Norco for pain relief. You would receive either Norco, Ibuprofen, or Acetaminophen for up to 7 days after your surgery. We are also studying if things like your gender or pre-surgery knee symptoms affect your pain or how much medication you use. This study is for people aged 18 to 80 who are having elective arthroscopic knee surgery. We will track your pain and medication use for two weeks after your surgery.

Study design
This interventional study plans to enroll 148 participants to compare different pain medications after knee surgery.
What's involved
You would take study medication daily for 7 days and report your pain and medication use daily for 14 days after surgery.
Compensation
Not stated in the trial record.
Follow-up
Your pain and medication use will be tracked daily for two weeks after your surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03858231

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

Recruiting
PHASE4Ages 18–80InterventionalTreatment
Sanford Health
~148 participants
Updated 2026-02-10 on ClinicalTrials.gov
What's tested:Norco 5Mg-325Mg TabletIbuprofen 600 mgAcetaminophen 325Mg Tab

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from Baseline Pain Assessment at 2 weeks
Measured over Daily for 2 weeks post-operatively
+1 more outcome measured
Knee Injuries
Pain, Postoperative
Opioid Use

NCT03858231

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Sanford Health

    Fargo, North Dakotastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Bruce Piatt, MD · PRINCIPAL_INVESTIGATOR · Sanford Health

Opens a ready-to-send draft in your own email app — review before sending.

  • Change from Baseline Pain Assessment at 2 weeksDaily for 2 weeks post-operatively

    Visual Analog Scale from 0 to 10 with 0 being no pain and 10 being worst possible, unbearable, excruciating pain

  • Change from Baseline Medication Use at 2 weeksDaily for 14 days post-operatively

    Patients will be asked how many study medication capsules have they taken.