This study aims to understand how thinking and memory change as people get older. Researchers will use special brain scans, including Amyloid PET scans (using florbetapir-F18) and Tau PET scans (using MK-6240), along with MRI scans and memory tests, to look for subtle brain changes that happen before memory problems appear. They want to see if these tests can help predict who might experience cognitive decline or develop Alzheimer's disease. The study is looking for 300 adults aged 60 or older who speak English or Spanish and are in good general health. The main goal is to see how a person's memory and thinking abilities change over time, specifically looking at changes in a score called the Clinical Dementia Rating - Sum of Box Score, measured at years 4 and 5 of the study. The current status of the study is unclear.

Study design

This is an interventional study with a planned enrollment of 300 participants. It aims to understand the factors leading to cognitive decline and Alzheimer's disease.

What's involved

Participants will undergo PET amyloid scans once at the beginning, and MRI and tau PET imaging at the beginning and after one year. They will also complete neurocognitive testing.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, change in Clinical Dementia Rating - Sum of Box Score, is measured at years 4 and 5 of the grant, suggesting long-term follow-up.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.