This study is looking into whether a skin patch containing transdermal estradiol and levonorgestrel can help improve bone density in women with anorexia nervosa. Anorexia nervosa often leads to significant bone loss, increasing the risk of fractures. This study will compare the patch to a placebo (an inactive patch) over 18 months. You may be able to join if you are a woman between 19 and 45 years old, have anorexia nervosa, are underweight, have stopped having periods (amenorrhea), and have low bone density in your spine or hip. The main goal is to see if the patch can increase bone mineral density after 18 months.

Study design

This is a randomized, placebo-controlled study involving 66 women. Participants will be randomly assigned to receive either the active patch or a placebo patch.

What's involved

Bone mineral density will be measured at the beginning of the study and again after 18 months.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 18 months, with bone mineral density measurements taken at the start and end of this period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.