WISE Pre-HFpEF Study for Coronary Microvascular Dysfunction
This study is looking at how small vessel disease (when tiny heart arteries narrow) might lead to pre-HFpEF (heart muscle not working well, even with good pumping). Researchers want to find better ways to prevent HFpEF. You might be able to join if you are an adult, male or female, with symptoms of heart ischemia (reduced blood flow to the heart) but no major blockages in your heart arteries, and your heart's pumping function is preserved. The study involves clinic visits, phone interviews, and potentially a heart MRI to track your progress over time.
- Study design
- This is an observational study, meaning researchers will watch and collect information without giving any specific interventions. It plans to include 180 men and women.
- What's involved
- You would have up to two clinic visits, a 6-week phone interview, four quarterly phone interviews in the first year, and ongoing annual phone interviews. A heart MRI might also be part of the first year's follow-up.
- Compensation
- Not stated in the trial record.
- Follow-up
- You will have annual follow-up phone interviews to track your progress after the initial year.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF
At a glance
Conditions
Where it's being run
2 sites across 2 statesStudy leadership
- C. Noel Bairey Merz, MD, FACC · PRINCIPAL_INVESTIGATOR · Cedars-Sinai Medical Center
Who to contact
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What this trial measures
- CMR imagingBaseline, Annual follow up
Change from Baseline at 1 year follow up will be assessed.
- Rest-stress Millar pressure-volume measurementBaseline
LV diastolic function will be measured using LV end-diastolic pressure, minimal rate of LV pressure change (dP/dtmin).