Thinking Zinc: A Study of Zinc Supplements on the Navajo Nation

This study, called "Thinking Zinc," is looking at whether taking a daily zinc supplement can help people living near abandoned uranium mines. These communities may be exposed to metals like uranium and arsenic, which can affect the immune system and overall health. The study will give participants Zinc Picolinate 15 Mg every day for six months. Researchers will measure metal levels, immune cell types (lymphocyte phenotyping), and inflammation markers (cytokine levels) at different times over nine months to see if the zinc supplement helps reduce the effects of metal exposure. You can join if you are between 21 and 64 years old, live in Blue Gap-Tachee, Arizona, or Red Water Pond Road Community, New Mexico, and are willing to provide blood and urine samples and take the supplement daily. The current status of the study is unclear.

Study design
This is an interventional study with a planned enrollment of 100 participants. The phase of the study is not specified.
What's involved
You would need to attend study visits on scheduled dates, provide blood and urine samples, and take a daily zinc supplement for six months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for nine months, with measurements taken at 0, 3, 6, and 9 months.

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NCT03908736

Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation

Recruiting
PHASE2Ages 21–64InterventionalBasic science
University of New Mexico
~100 participants
Updated 2026-06-04 on ClinicalTrials.gov
What's tested:Zinc Picolinate 15 Mg

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Metal biomonitoring to compare change from baseline versus zinc supplement
Measured over Visit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)
+3 more outcomes measured
DNA Damage
Immune System Disorder
1 sites across 1 states
New Mexico1

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Eligibility criteria

Inclusion

Men or women between the ages of 21 and 64 years of age
Lives in or near the participating communities of Blue Gap-Tachee Arizona or Red Water Pond Road Community New Mexico
Willing to provide blood and urine samples
Willing to attend study visits on scheduled dates
Willing to take a daily zinc supplement

Exclusion

Women who are pregnant or nursing or women who plan to become pregnant during the course of the study.
Individuals who have self-reported diabetes, report that they are undergoing treatment for diabetes, or are currently taking medication for diabetes.
Known or suspected allergy to zinc.
Individuals previously diagnosed with syndromes of copper homeostasis (Menkes disease or Wilsons disease).
Individuals consuming zinc supplements or multivitamins and are unwilling to stop for the duration of the study.
  • Metal biomonitoring to compare change from baseline versus zinc supplementVisit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)

    urinary and serum metal levels to be measured by inductively coupled plasma mass spectrometry

  • Lymphocyte phenotyping to compare change from baseline versus zinc supplementVisit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)

    Lymphocyte phenotypes will be measured in blood samples

  • Cytokine level measurement to compare change from baseline versus zinc supplementVisit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)

    A cytokine panel will be used to measure levels of multiple cytokines in blood samples

  • Autoantibody measurement to compare change from baseline versus zinc supplementVisit 1 (0 months-baseline 1), Visit 2 (3 months-baseline 2), Visit 3 (6 months-zinc 1), Visit 4 (9 months-zinc 2)

    Autoantibody panel titers will be measured in blood samples