Comparing Accelerated vs. Standard Corneal Crosslinking for Keratoconus

This study is comparing two ways to perform corneal crosslinking for people with keratoconus or corneal ectasia (a condition where the cornea thins and bulges). Researchers are testing if using riboflavin 0.1% eye drops with 9 mW/cm2 UVA light for 10 minutes (accelerated) works as well as using riboflavin 0.1% eye drops with 3 mW/cm2 UVA light for 30 minutes (standard). The study aims to see which method is better at stopping the cornea from getting more curved. You might be able to join if you are at least 10 years old and have documented keratoconus or ectasia after refractive surgery. The study is looking for 510 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 510 participants to compare two different corneal crosslinking methods.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main measurement of success is taken at 6 months after treatment.

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NCT03922542

Comparison of Standard vs. Accelerated Corneal Crosslinking

Recruiting
PHASE2Ages 10+InterventionalTreatment
Price Vision Group
~510 participants
Updated 2025-07-31 on ClinicalTrials.gov
What's tested:riboflavin 0.1%

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in maximum keratometry
Measured over 6 months
Keratoconus
Ectasia Corneal
1 sites across 1 states
Indiana1
  • Francis W Price, Jr., MD · PRINCIPAL_INVESTIGATOR · Price Vision Group

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Eligibility criteria

Inclusion

Documented keratoconus or ectasia after refractive surgery

Exclusion

Insufficient corneal thickness
Ocular condition that may predispose the eye to complications
History of chemical injury or delayed epithelial healing
Condition that would interfere with or prolong epithelial healing
Known sensitivity to treatment medications
Pregnancy
  • Change in maximum keratometry6 months

    assessed by corneal tomography