Gene Expression Changes in Young and Geriatric Skin
This study is looking at how artificial sunlight (ultraviolet B radiation, or UVB) affects the skin of young adults compared to older adults. Researchers believe that young skin has more of a protein called Insulin-Like Growth Factor 1 (IGF-1), which might help protect against sun damage. This study will give some participants IGF-1 and others no IGF-1, then expose their skin to UVB. The main goal is to see how genes involved in protecting skin from UVB damage change in both young and older skin after IGF-1 treatment. You could join if you are a male or female with white skin (Fitzpatrick types I and II), aged 21-30 or 65 and older. The study is currently recruiting 24 participants, but its status is unclear.
- Study design
- This is an interventional study with 24 planned participants. It compares the effects of Insulin-Like Growth Factor 1 to no Insulin-Like Growth Factor 1.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint is measured at 2 days after baseline.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Gene Expression Changes In Young and Geriatric Skin
At a glance
Conditions
NCT03932162
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Wright State Physicians
Fairborn, Ohiono site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jeffrey B Travers, MD, PhD · PRINCIPAL_INVESTIGATOR · Wright State University
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Change in expression genes involved in protecting skin cells from UVB damage in younger skin and geriatric skin injected with IGF-1 from baseline2 Days
Expression genes involved in protecting skin cells from UVB damage, including p21, xeroderma pigmentosum (XPC), and polymerase eta, will be higher following UVB exposure in younger skin and geriatric skin injected with IGF-1 than in geriatric skin injected with saline as a control.