Sulforaphane for Doxorubicin-Associated Heart Problems in Breast Cancer

This study is looking at whether a nutritional supplement called sulforaphane can help protect the heart from damage caused by doxorubicin (DOX) chemotherapy in breast cancer patients. Doxorubicin is an important cancer treatment, but it can sometimes weaken the heart. Researchers want to see if sulforaphane, which is found in broccoli sprouts, can prevent this heart damage while still allowing doxorubicin to fight cancer effectively. You might be able to join if you are an adult breast cancer patient (ages 18-89) who will be treated with a doxorubicin-containing regimen and do not have certain heart conditions. The study will measure changes in your heart function after doxorubicin treatment, with or without sulforaphane, to see if the supplement is helpful. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 70 participants. You would receive either sulforaphane or a placebo (an inactive pill) daily for 12 weeks, without knowing which one you are taking.
What's involved
You would take caplets daily for 12 weeks. Your heart function will be measured at the beginning of the study and again one year later.
Compensation
Not stated in the trial record.
Follow-up
Your heart function will be assessed at baseline and one year from the baseline assessment.

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NCT03934905

Protective Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac Dysfunction

Recruiting
PHASE1Ages 18–89InterventionalPrevention
Texas Tech University Health Sciences Center
~70 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:sulforaphanePlacebo Oral Tablet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in cardiac function after DOX therapy with or without sulforaphane through diagnostic studies
Measured over At baseline and 1 year from baseline assessment.
Anthracycline Related Cardiotoxicity in Breast Cancer
1 sites across 1 states
Texas1

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  • Change in cardiac function after DOX therapy with or without sulforaphane through diagnostic studiesAt baseline and 1 year from baseline assessment.

    2D Echo will be used to measure cardiac function amongst patients on DOX therapy who are exposed to sulforaphane or placebo.