Back to search results

Cognitive Rehabilitation for Low-Grade Gliomas

This study is looking at different ways to help people with low-grade gliomas (a type of brain tumor) who experience problems with thinking, memory, and attention. These issues can happen because of the tumor itself or its treatments. The study will test several interventions: the ReMind iPad app, which offers cognitive training and teaches coping skills; daily text messages focused on health and cognitive strategies; and in-person or telehealth cognitive rehabilitation sessions. Researchers want to see if these methods can improve cognitive function and quality of life. You might be able to join if you are at least 18 years old, have a low-grade brain tumor, speak English, have internet access and a text-enabled phone, and receive MRI scans at UCSF. The study aims to see how many people complete the interventions and if these treatments can prevent a significant decline in memory and working memory over time. The current status of the study is unclear.

Study design
This is an interventional study with a planned enrollment of 117 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will engage with interventions like an iPad app, daily text messages, or in-person/telehealth cognitive rehabilitation. The study will measure completion of exercises over 9 months and track cognitive decline for up to 3 years.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 3 years to detect any decline in working memory or verbal learning.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03948490

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Recruiting
NAAges 18+InterventionalSupportive care
University of California, San Francisco
~117 participants
Updated 2026-07-14 on ClinicalTrials.gov
What's tested:ReMind iPad appHealthy SMS textingIn-person cognitive rehabilitationTelehealth cognitive rehabilitation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of subjects who complete all of the intervention exercises for each cohort (Arm 1)
Measured over 9 months
+1 more outcome measured

Conditions

Low-grade Glioma

Explore related trials

Cognitive DysfunctionLow Grade GliomaIDH1 wt Allele

NCT03948490

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of California, San Francisco

    San Francisco, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jennie Taylor, MD, MPH · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Jennie Taylor, MD, MPH
[email protected]
415-353-2966
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Histologically confirmed low grade supratentorial primary brain tumor
\>= 18 years old
Life expectancy \> 12 weeks
Karnofsky performance status (KPS) \>= 70
Must speak and be able to read English fluently
Must have access to the internet
Must have text enabled cellphone
Must be receiving MRI scans at University of California, San Francisco (UCSF)
Must be clinically stable and off treatment (e.g. radiation or chemotherapy) for ≥ 3 months
Must be \>= 6 months from craniotomy
Must have subjective complaints of cognitive deficits
Must have adequate seizure control and be on a stable, or decreasing, dose of anti-epileptics
Must score \<= 1 SD below normal on ≥ 2 or more domains of baseline neuropsychological assessments
Have a presumed lower grade IDH-mutated primary brain tumor and either be undergoing definitive surgery or have had surgical resection within the last 4 months.
Prior surgery is allowed if they have not received additional tumor directed treatment.
\>= 18 years old
Must speak and be able to read English fluently.
Plan to continue to care in neuro-oncology at UCSF
Must be receiving MRI scans.

Exclusion

Diagnosis or evidence of any of the following:
• Glioblastoma
• Extra-axial disease (i.e. meningioma)
• Infra-tentorial disease
Are not able to comply with study and/or follow-up procedures
Are unable to complete or score \>= 3 cognitive tests at baseline, which is indicative that patients would be unable to complete the cognitive rehabilitation interventions
Are acutely suicidal, psychotic, and/or gravely disabled.
Patients who, based on the neuropsychologist's opinion, are unable to participate in cognitive testing and/or cognitive rehab secondary to significant neurologic deficit
Diagnosis or evidence of any of the following:
• Primary brain tumor classified as CNS WHO Grade 4
• Extra-axial disease (i.e. meningioma)
Are not able to comply with study and/or follow-up procedures
Have acute psychiatric issues (suicidality, active psychosis, gravely disabled)

What this trial measures

  • Percentage of subjects who complete all of the intervention exercises for each cohort (Arm 1)9 months

    The intervention will be considered feasible for a larger-scale efficacy study if greater than 80% of the subjects complete the intervention. Patients will be replaced if they drop out of the intervention (either by declining their first follow-up visit for Cohort 1 in-person rehab; declining to participate in the Cohort 2 ReMind intervention; or by texting the word "STOP" in the Cohort 3 short message service (SMS) texting intervention)) within the first 14 days. These patients will be replaced. All other patients will be evaluable for feasibility if they remain in the Cohort past the first 14 days of the intervention

  • Number of participants who show a decline of >= 1.5 SD from baseline on the Wechsler Adult Intelligence Scale IV (WAIS-IV) Working Memory Score or Hopkins Verbal Learning Test (HVLT) (Arm 2)3 years

    Detect a decline of greater than 1.5 standard deviation (SD) compared to baseline on WAIS-IV Working Memory Score or HVLT during the 36 month follow-up after surgery