Pulmonary Hemodynamics During Exercise - Research Network

This observational study is looking at how blood pressure in your lungs (pulmonary hemodynamics) changes during exercise. Researchers will use information from a right heart catheterization (a procedure where a thin tube is inserted into your heart to measure pressures) performed during exercise, along with other routine clinical tests. This study aims to understand how these measurements relate to long-term outcomes for people with pulmonary circulation diseases. You may be able to join if you are over 18, have an intermediate or high chance of having high blood pressure in your lungs (pulmonary hypertension, or PH) based on an echocardiogram, or have unexplained shortness of breath, and are already scheduled for a right heart catheterization at rest and during exercise. The study will look at how many participants die or need a lung transplant over a 6-year period. The current recruitment status is unclear.

Study design
This is an observational study that plans to include 1500 participants. It is not a randomized trial and does not involve a specific phase of drug development.
What's involved
Participants will undergo a right heart catheterization during exercise due to clinical reasons. Results from this and other routine clinical tests will be included in a registry.
Compensation
Not stated in the trial record.
Follow-up
Participants will be observed for 6 years to track outcomes like death or lung transplantation.

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NCT03954574

Pulmonary Hemodynamics During Exercise - Research Network

Recruiting
Not specifiedAges 18+Observational
Medical University of Graz
~1,500 participants
Updated 2025-04-27 on ClinicalTrials.gov
What's tested:assessment of pulmonary hemodynamics during exercise by right heart catheterization

At a glance

Recruiting sites
32 of 32 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of Participants who die during observation
Measured over 6 years
+1 more outcome measured
Pulmonary Circulation Diseases
32 sites across 19 states
Germany5
France4
United Kingdom4
Massachusetts2
Minnesota2
Italy2
Arizona1
California1
  • Horst Olschewski, MD · STUDY_CHAIR · Medical University of Graz
  • Philippe Herve, MD · STUDY_CHAIR · Centre Chirugical Marie Lannelongue

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Eligibility criteria

Inclusion

Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise
Written informed consent of participating subjects after being fully briefed (for prospective analysis)

Exclusion

Patients with incomplete hemodynamic data at rest or exercise
Patients without sufficient follow-up data (information on survival / lung transplantation)
advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases
advanced heart failure with pulmonary arterial wedge pressure (PAWP) \> 18 mmHg at rest
uncontrolled systemic arterial hypertension (RR values \> 160/100 mmHg at rest)
FEV1\<50% predicted
TLC\<60% predicted
  • Number of Participants who die during observation6 years

    The investigators aim to assess the prognostic relevance of pulmonary hemodynamics during exercise as assessed by right heart catheterization by using a multi-centre approach and to identify independent predictors of adverse events. Separate data sets will be analysed for the retrospective and prospective Evaluation.

  • Number of Participants undergoing lung Transplantation during observation6 years

    Occurrences of lung transplantations