This study, called CAVIARDS, is looking at whether a careful, individualized approach to using a breathing machine (ventilator) can improve outcomes for people with Acute Respiratory Distress Syndrome (ARDS). ARDS is a serious lung condition where the lungs are inflamed and have trouble stretching, making breathing difficult. The study compares two ways of using the ventilator: one where settings are adjusted based on your specific lung measurements (Respiratory Mechanics), and another using standard ventilator settings. Researchers want to see if the individualized approach can reduce the number of deaths within 60 days. This study includes both people with ARDS caused by COVID-19 and those with ARDS from other causes. You might be able to join if you are 18 or older and have moderate to severe ARDS.

Study design

This is a multicenter randomized controlled clinical trial with an adaptive design, planning to enroll 740 participants. It compares two different mechanical ventilation strategies.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed to assess all-cause mortality at 60 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.