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Observational Study of Eosinophilic Esophagitis in Children

This study is looking at children and young adults with Eosinophilic Esophagitis (EoE), a condition where a type of white blood cell (eosinophil) builds up in the esophagus (the tube connecting your mouth to your stomach). Researchers want to understand how EoE symptoms, changes seen during endoscopy (a procedure to look inside the esophagus), and tissue samples change over time during routine medical care. They will also track inflammatory markers in blood and tissue samples. The study aims to learn more about how EoE progresses and how different patients experience the disease. You can join if you are between 1 and 65 years old, have a known EoE diagnosis, and experience symptoms like difficulty swallowing, vomiting, or abdominal pain, or have specific findings during an endoscopy. This is an observational study, meaning no new treatments are being tested; researchers are simply collecting information from your regular clinic and endoscopy visits.

Study design
This is a single-center observational study planning to enroll 1500 participants. It is not a randomized or blinded study.
What's involved
Participants will have their medical information, including symptoms, endoscopy findings, and lab results, entered into a database during routine clinic and/or endoscopy visits. Blood and biopsy specimens will also be collected.
Compensation
Not stated in the trial record.
Follow-up
The study will track symptoms, endoscopy findings, and histology for 10 years, and inflammatory markers in blood and biopsies for 10 years.

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NCT03980886

Characteristics and Inflammatory Markers in Children With Eosinophilic Esophagitis (EoE)

Recruiting
Not specifiedAges 1–65Observational
University of California, San Diego
~1,500 participants
Updated 2026-07-07 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The longitudinal trajectory of symptoms, endoscopy, and histology in pediatric EoE during routine clinical care
Measured over 10 years
+1 more outcome measured

Conditions

Eosinophilic Esophagitis

Explore related trials

Eosinophilic Esophagitis

Where it's being run

1 sites across 1 states
California1

Who to contact

Angie Rodriguez Verdin, BS
[email protected]
8589661700 · ext. 225005
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Have a known EoE diagnosis
Complain of dysphagia, vomiting, or abdominal pain, especially if recalcitrant to acid blocking therapy (but does not have to be recalcitrant to acid blocking medications)
Present with food impaction
Present with esophageal stricture
Have characteristic endoscopic findings of EoE of pallor, linear furrows, lichenification, white plaques, or concentric rings

Exclusion

None

What this trial measures

  • The longitudinal trajectory of symptoms, endoscopy, and histology in pediatric EoE during routine clinical care10 years

    Outcome measures of symptoms, histology, endoscopy, and lab values such as peripheral eosinophilia and cortisol procured at each clinical and/or endoscopy visit will be entered and tracked in a UCSD/RCHSD de-identified database in order to understand their longitudinal trajectory during routine clinical care

  • The longitudinal trajectory of inflammatory markers in blood and biopsies in pediatric EoE during routine clinical care10 years

    The presence and severity of inflammatory markers and cells over time in specimens collected during routine endoscopy and biopsy will be measured to understand their alignment with outcome measures of symptoms, histology, and endoscopy