Neural Control of Kidney Blood Flow During Exercise in African American Adults

This study is looking at how kidney blood flow changes during exercise and stress in healthy young African American adults compared to White adults. Researchers want to see if African American adults have a larger decrease in kidney blood flow during activities like cycling exercise, a cold hand test (cold pressor test), and a mental math test (mental stress test). Understanding these differences could help explain why heart and kidney problems are more common in African American adults. The study aims to enroll 32 participants and is currently unclear about its recruitment status. You can join if you are a healthy African American or White adult between 18 and 35 years old, born in the U.S., with both parents of the same racial identity, recreationally active, and fluent in English.

Study design
This is an interventional study planning to enroll 32 participants. It compares kidney blood flow responses between African American and White adults during different activities.
What's involved
You would visit the research lab twice to perform a fitness test, cycling exercise while lying down, a cold hand test, and a mental math test.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT03981640

Neural Control of Kidney Blood Flow During Exercise in African American Adults

Completed
NAAges 18–35InterventionalBasic science
University of Massachusetts, Boston
~33 participants
Updated 2026-08-25 on ClinicalTrials.gov
What's tested:Acute exerciseCold pressor testMental stress test

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in renal vascular resistance during acute exercise
Measured over Pre-acute exercise and during steady-state exercise
+2 more outcomes measured
Healthy
1 sites across 1 states
Massachusetts1
  • Rachel C Drew, PhD · PRINCIPAL_INVESTIGATOR · University of Massachusetts, Boston

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Self-report as either African American or White racial identity
Born in United States
Both biological parents identify as same racial identity as participant
Recreationally active (participating in physical activity for at least 20 minutes per day, at least three times per week, but not training for competitive events)
Fluent in English

Exclusion

Hispanic or Latino
Females who are pregnant or lactating
Cardiovascular or renal disease
Hypertension (blood pressure of more than or equal to 130/80 mmHg)
Diabetes
Obesity (body mass index of more than or equal to 30 kg/m2)
Smoker/Tobacco user
Acute medical conditions
Taking prescribed cardiovascular, antihypertensive, or renal medications
  • Change in renal vascular resistance during acute exercisePre-acute exercise and during steady-state exercise

    For the acute exercise intervention, the percent change from pre-acute exercise to during steady-state exercise will be assessed.

  • Change in renal vascular resistance during cold pressor testPre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test

    For the cold pressor test intervention, the percent change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.

  • Change in renal vascular resistance during mental stress testPre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test

    For the mental stress test intervention, the percent change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.