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Dietary Proteins and Glucose Metabolism Study

This study is looking into how different types of protein in your diet affect your body's ability to manage sugar (glucose metabolism). Researchers are testing high protein diets using either animal or plant-based proteins, and comparing whole foods to protein isolates (concentrated protein powders). They want to see how these diets impact insulin sensitivity (how well your body uses insulin to control blood sugar) and your body's response to meals. You might be able to join if you are between 21 and 70 years old, have a BMI between 24.5 and 32.5, and typically eat less than 0.9 grams of protein per kilogram of your body weight per day. The study aims to enroll 100 people, but its current status is unclear.

Study design
This is an interventional study, meaning participants will receive specific dietary changes. It plans to enroll 100 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Researchers will measure outcomes up to 12 weeks after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT03994367

Animal and Plant Proteins and Glucose Metabolism

Recruiting
NAAges 21–70InterventionalPrevention
University of Missouri-Columbia
~100 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:High animal protein isolateHigh animal protein whole foodHigh plant protein isolateHigh plant protein whole food

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
24-hour plasma glucose concentration
Measured over up to 12 weeks after the intervention
+1 more outcome measured

Conditions

Metabolic Syndrome
Metabolic Syndrome, Protection Against
Glucose Metabolism Disorders

Explore related trials

Glucose Metabolism DisorderMetabolic Syndrome

Where it's being run

1 sites across 1 states
Missouri1

Study leadership

  • Bettina Mittendorfer · PRINCIPAL_INVESTIGATOR · University of Missouri-Columbia

Who to contact

BETTINA MITTENDORFER
[email protected]
618-610-3465
Email the study team

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Eligibility criteria

Inclusion

age: ≥21 and ≤70 years;
BMI: \>24.5 and \<32.5 kg/m2;
habitual protein intake \<0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and
weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study.

Exclusion

prediabetes or type 2 diabetes;
evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate \<60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g);
vegetarians or vegans;
intolerance or allergies to ingredients in the metabolic meal or intervention diet;
take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcomes;
received antibiotic or antifungal treatment (which affect the microbiome and therefore microbial metabolite production) 2 months before entering the study;
consume tobacco products or excessive alcohol (women: \>14 drinks/week; men: \>21 drinks/week);
evidence of significant organ system dysfunction or diseases (e.g., cirrhosis), and
unwilling or unable to provide informed consent.

What this trial measures

  • 24-hour plasma glucose concentrationup to 12 weeks after the intervention
  • Insulin sensitivity assessed as insulin-mediated glucose disposal during a hyperinsulinemic-euglycemic clamp procedureup to 12 weeks after the intervention