Gait Rehabilitation for Veterans with Lower Limb Amputation

This study is looking for Veterans aged 40 to 89 who have had a non-traumatic lower limb amputation (amputation not caused by an injury) and experience uneven walking. You may also have diabetes or peripheral artery disease (a condition affecting blood circulation). The study is testing two different training programs: "Error-augmentation gait training" and "Error-correction gait training." Both programs use treadmill exercises to help improve how evenly you walk. There's also a supervised walking group that doesn't focus on correcting uneven steps. The main goal is to see if these training programs can make your steps more symmetrical (even) right after the training and 12 weeks later. The study aims to enroll 54 participants.

Study design
This interventional study plans to enroll 54 participants. It compares two different gait training programs against a supervised walking program.
What's involved
You would participate in 8 training sessions over 4 weeks for one of the gait training programs or the supervised walking program.
Compensation
Not stated in the trial record.
Follow-up
Your step length symmetry will be measured at the end of the intervention and again 12 weeks after the intervention ends.

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NCT03995238

Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation

Recruiting
NAAges 40–89InterventionalTreatment
VA Office of Research and Development
~54 participants
Updated 2026-04-13 on ClinicalTrials.gov
What's tested:Error-augmentation gait trainingError-correction gait trainingSupervised walking

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Step Length Symmetry
Measured over Change from baseline (pre-intervention) to intervention end, persisting at 12 weeks after intervention end.
Transtibial Amputation
Peripheral Artery Disease
Diabetes Mellitus
2 sites across 2 states
Colorado1
Virginia1
  • Cory L. Christiansen, PhD · PRINCIPAL_INVESTIGATOR · Rocky Mountain Regional VA Medical Center, Aurora, CO

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Eligibility criteria

Inclusion

Unilateral, non-traumatic, transtibial amputation
Diabetes mellitus and/or peripheral artery disease
Able to ambulate in the community without assistive device
Step length asymmetry during walking (\>1.0 asymmetry index.)
6 months since amputation

Exclusion

Unstable heart condition
Including unstable angina, uncontrolled cardiac dysrhythmia, acute myocarditis, hypertension, and acute pericarditis
Acute systemic infection
Active cancer treatment
Traumatic or cancer related amputation etiology
  • Step Length SymmetryChange from baseline (pre-intervention) to intervention end, persisting at 12 weeks after intervention end.

    Measurement of step length symmetry by overground walking on GAITRite mat and kinetic and kinematic measurements using 3-D motion capture system.