Lumify™ for Eye Redness in Glaucoma Patients

This study is looking at how Lumify™ (brimonidine tartrate ophthalmic solution 0.025%) affects eye redness, eye pressure (intraocular pressure), and eyelid position in people with glaucoma. Glaucoma is a group of conditions that can damage the optic nerve and cause vision loss. Lumify™ is an FDA-approved eye drop for reducing eye redness. You might be able to join if you are over 18, have primary open-angle glaucoma, and have been using brimonidine 0.1%, 0.15%, or 0.2% eye drops for at least six weeks. The study will measure eye redness at 5, 15, and 30 minutes after using the eye drops. The study is currently recruiting about 60 participants.

Study design
This is an interventional study involving about 60 participants. It compares a single dose of Lumify™ to a single dose of sterile balanced saline solution.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your eye redness will be measured at 5, 15, and 30 minutes after receiving the eye drop.

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NCT04007276

The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Tulane University
~60 participants
Updated 2025-10-01 on ClinicalTrials.gov
What's tested:brimonidine tartrate ophthalmic solution 0.025%sterile balanced saline solution

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ocular redness
Measured over 5 minutes after application of eye drop
+4 more outcomes measured
Glaucoma
Glaucoma, Open-Angle
Glaucoma; Drugs
Droopy Eyelid
Ptosis
Glaucoma, Primary Open Angle
1 sites across 1 states
Louisiana1
  • Ze Zhang, MD · PRINCIPAL_INVESTIGATOR · Tulane University

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Eligibility criteria

Inclusion

Age \> 18 years
Diagnosis of primary open angle glaucoma
Willing and able to give informed consent
Current and greater than 6 weeks of brimonidine 0.2%, 0.15% or 0.1% use

Exclusion

Pregnancy
Prisoners
Known allergy or sensitivities to brimonidine
No surgery within the past 6 months
No history of lid surgery or botox
Any other significant ophthalmologic disorder or condition with relevant effect on ocular redness, IOP, or eyelid position as evaluated by principal investigator
Inability to sit comfortably for 30 minutes
Prior use of eye whiteners (eg, vasoconstrictors), decongestants, antihistamines, or phenylephrine dilating drops within 1 week of study
  • Ocular redness5 minutes after application of eye drop

    Scoring of ocular redness on clinical photographs using the the Investigator Ocular Redness Scale (0-4; 0 = no ocular redness, 4 = extremely severe ocular redness)

  • Ocular redness15 minutes after application of eye drop

    Scoring of ocular redness on clinical photographs using the the Investigator Ocular Redness Scale (0-4; 0 = no ocular redness, 4 = extremely severe ocular redness)

  • Ocular redness30 minutes after application of eye drop

    Scoring of ocular redness on clinical photographs using the the Investigator Ocular Redness Scale (0-4; 0 = no ocular redness, 4 = extremely severe ocular redness)

  • Ocular redness60 minutes after application of eye drop

    Scoring of ocular redness on clinical photographs using the the Investigator Ocular Redness Scale (0-4; 0 = no ocular redness, 4 = extremely severe ocular redness)

  • Intraocular pressure60 minutes after application of eye drop

    Measurement of intraocular pressure using handheld tonometer (TonoPen)