Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients
This observational study is looking at immune cells called Myeloid-Derived Suppressor Cells (MDSCs) in people with breast cancer. Researchers want to understand how these MDSCs, which are considered "unfavorable" immune cells, might stop "favorable" immune cells called Natural Killer Cells from working properly. You might be able to join if you are 18 or older, can give informed consent, and have Stage I-III breast cancer. The study involves collecting specimens from you. The goal is to see how strongly MDSCs inhibit Natural Killer Cells, with measurements taken for up to one year. The study plans to enroll 99 participants, but its current status is unclear.
- Study design
- This is an observational study planning to enroll 99 participants. It does not involve a specific treatment intervention.
- What's involved
- You would provide specimens, which are obtained from patients being treated for breast cancer.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint is measured for up to one year.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- William Carson, MD · PRINCIPAL_INVESTIGATOR · Ohio State Comprehensive Cancer Center
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Isolate unfavorable immune cells MDSC from the peripheral blood or tumors of study subjects and test how strongly they inhibit function of favorable immune cells called Natural Killer Cells.up to 1 year
Function of Natural Killer Cells will be studied by measuring their ability to kill target cancer cells coated with monoclonal antibodies. isolate unfavorable immune cells called Myeloid Derived Suppressor Cells (MDSC) from the peripheral blood or the tumors of study subjects and test how strongly they inhibit function of favorable immune cells called Natural Killer Cells. Function of Natural Killer Cells will be studied by measuring their ability to kill target cancer cells coated with monoclonal antibodies.