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Understanding Genetic Risk for Type 2 Diabetes

This study is looking at how your genes might affect your risk of developing type 2 diabetes, even if you don't have it yet. We're testing if people with a high genetic risk score for type 2 diabetes have trouble processing sugar compared to those with a low genetic risk. If you are between 10 and 70 years old, have a certain BMI, and have previously participated in the UPenn Biobank or Center for Applied Genomics Biobank, you might be able to join. You cannot have a prior diagnosis of diabetes or be taking certain medications. The study involves drinking a 75g glucose beverage (like Glucola or Trutol) and having a whole body DXA scan (a type of X-ray to measure body fat). We will measure your glucose response over four hours to see how your body handles sugar. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 100 participants. It is not specified if it is randomized or blinded.
What's involved
You would visit the study site fasting, drink a glucose beverage, and have blood samples taken over four hours. You would also undergo a whole body DXA scan.
Compensation
Not stated in the trial record.
Follow-up
Glucose response will be measured over four hours during the study visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04024631

Phenotyping Genetic Risk for Type 2 Diabetes

Recruiting
NAAges 10–70Interventional
University of Pennsylvania
~100 participants
Updated 2025-09-10 on ClinicalTrials.gov
What's tested:75g glucose beverage (Glucola, Trutol, or similar brand)DXA, whole body

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Glucose response to an oral glucose load
Measured over samples will be collected over four hours and these results will be used to calculate area under the curve

Conditions

Diabetes Mellitus, Type 2
Genetics

Explore related trials

Type 2 Diabetes Mellitus

Where it's being run

2 sites across 1 states
Pennsylvania2

Study leadership

  • Jessica R Wilson, MD, MS · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
  • Lorraine Levitt Katz, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital of Philadelphia

Who to contact

Jessica R Wilson, MD, MS
[email protected]
215 898-3389
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Age 10-70 years
Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher

Exclusion

prior diagnosis of type 1, type 2, or secondary diabetes
use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
acute illness that may impact insulin and glucose dynamics
pregnancy
hypothalamic obesity or related genetic disorder of metabolism
recent systemic chemotherapy use
gastrointestinal impairment or surgery that may impact absorption
anemia
major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
inability to comply with study protocol

What this trial measures

  • Glucose response to an oral glucose loadsamples will be collected over four hours and these results will be used to calculate area under the curve

    Glucose area under the curve after the 75g glucose beverage