This study is testing if a medication called Etanercept can help reduce the severity of tinnitus (ringing in the ears) that is caused by blast or noise exposure, or by a traumatic brain injury (TBI) or concussion. You could be eligible if you are 18 or older, have moderate to severe tinnitus (a score of 25 or higher on the Tinnitus Functional Index questionnaire) linked to these causes, and can provide written consent. Participants will be randomly assigned to receive either Etanercept or a saline solution (placebo). The main goal is to see if Etanercept significantly lowers your tinnitus distress after 12 weeks, as measured by the Tinnitus Functional Index. The study also aims to see if Etanercept improves hearing and reduces how loud you perceive your tinnitus to be.

Study design

This is an interventional study planning to enroll 88 participants. You would be randomly assigned to one of two groups: receiving Etanercept or a placebo.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint is measured at 12 weeks, and investigators will explore sustained effects over time.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.