This study is looking at the best way to treat early-stage endometrial cancer (cancer of the lining of the uterus). Doctors usually remove the uterus, fallopian tubes, and ovaries, and sometimes lymph nodes. Removing lymph nodes can sometimes cause side effects like swelling (lymphoedema). This study compares two surgical approaches: one that uses a special dye (ICG +/- Methylene Blue Dye) to find and remove only the first lymph nodes (sentinel node biopsy, or SNB) that cancer might spread to, and another that removes the uterus, tubes, and ovaries without removing lymph nodes. The goal is to see if SNB is as safe and effective, and doesn't cause more problems or costs, compared to not removing lymph nodes. You may be able to join if you are a woman over 18 with early-stage endometrial cancer.

Study design

This is an interventional study planning to enroll 760 participants. It compares two different surgical procedures for endometrial cancer.

What's involved

Participants will undergo surgery, either with a sentinel node biopsy or without retroperitoneal node dissection. Recovery will be measured at 12 months, and disease-free survival at 4.5 years.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 4.5 years after surgery to assess disease-free survival.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.