Indocyanine Green (ICG) Guided Tumor Resection for Solid Tumors

This study is looking at how well a drug called Indocyanine Green (ICG) can help surgeons find and remove solid tumors or lymphoma in children. ICG is an FDA-approved drug that is given through a vein before surgery. During the operation, a special imaging system (EleVision™ IR Platform) will be used to see if the ICG helps highlight the tumor and its edges. This could help surgeons make sure they remove all of the tumor, which is very important for a cure. The main goal is to see how accurately ICG can identify the tumor during surgery. You might be able to join if you have a primary or relapsed solid tumor or lymphoma that needs to be removed. You cannot join if you have iodide allergies, benign (non-cancerous) pathology, or brain tumors. The study is currently unclear about its recruitment status and plans to enroll 230 participants.

Study design
This is a single-center, open-label study, meaning both you and the study team will know you are receiving Indocyanine Green. It plans to include 230 participants.
What's involved
You will receive a single dose of Indocyanine Green intravenously the day before surgery. Your tumor will be imaged during surgery, and the study participation will last until 24 hours after surgery.
Compensation
Not stated in the trial record.
Follow-up
Your direct participation in the trial will last until 24 hours post-surgery.

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NCT04084067

Indocyanine Green (ICG) Guided Tumor Resection

Recruiting
PHASE1All AgesInterventionalDiagnostic
St. Jude Children's Research Hospital
~230 participants
Updated 2026-04-30 on ClinicalTrials.gov
What's tested:Indocyanine Green

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sensitivity rates of the ICG guided neoplastic disease identification
Measured over up to 24 hours post-surgery
Neoplastic Disease
Solid Tumor
1 sites across 1 states
Tennessee1
  • Lindsay Talbot, MD · PRINCIPAL_INVESTIGATOR · St. Jude Children's Research Hospital

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Eligibility criteria

Inclusion

Patients with a primary or relapsed solid tumor or lymphoma who require excision of the tumor or metastatic lesions.

Exclusion

Subjects with a history of iodide allergies.
Inability or unwillingness of research participant or legal guardian/representative to give written informed consent.
Patients with benign pathology.
Patients with brain tumors.
Pregnant female.
Patients with unilateral Wilms Tumor.
  • Sensitivity rates of the ICG guided neoplastic disease identificationup to 24 hours post-surgery

    Participants in each of the primary objective categories will be evaluated for this objective.