Microvascular Dysfunction in Obesity Study

This study is looking at how exercise affects blood vessel health in people with obesity. Researchers want to see if eight weeks of interval exercise training can reduce reactive oxygen species (ROS), which are harmful molecules that contribute to diseases like heart disease and diabetes. You may be able to join if you are between 18 and 45 years old, have obesity, and have been weight stable for the past six months. Women must be premenopausal and using certain hormonal birth control. The study aims to enroll 25 participants, but its current recruitment status is unclear.

Study design: This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 25 participants.
What's involved: You would participate in eight weeks of interval exercise training. Specific details about visits or other procedures are not provided.
Compensation: Not stated in the trial record.
Follow-up: Researchers will measure changes in reactive oxygen species (ROS) from the beginning of the study to week 8.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Microvascular Dysfunction in Obesity

Recruiting

NAAges 18–45InterventionalBasic science

Florida State University

~25 participants

Updated 2025-12-11 on ClinicalTrials.gov

What's tested:Exercise

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Reactive oxygen species (ROS)

Measured over change from week 0 to week 8

Conditions

Obesity

Endothelial Dysfunction

Where it's being run

1 sites across 1 states

Florida1

Study leadership

Robert C Hickner, PhD · PRINCIPAL_INVESTIGATOR · Florida State University

Who to contact

Robert C Hickner, PhD

[email protected]

850-644-1375

Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime

Eligibility criteria

Inclusion

There will be no restrictions with regard to race, sex, or socioeconomic status.

Women will be premenopausal

Women will be on combined estrogen/progestin hormonal contraceptive therapy (oral pill, transdermal patch or vaginal ring).

Sedentary obese individuals will have been weight stable for the preceding 6 months.

Sedentary obese individuals will have the Metabolic Syndrome as defined according to the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III).

Individuals with the Metabolic Syndrome will have at least three of the following:

Exclusion

Subjects participating in purposeful endurance exercise training (\>20 min/day, \>1 day/week) will be excluded.

Pre-menopausal female subjects must not be pregnant or lactating, and must have had regular menstrual cycles for the past year.

Individuals taking medications that may affect central or peripheral circulation,

Individuals on nonsteroidal anti-inflammatory agents or serotonin reuptake inhibitors,

Individuals who smoke or chew tobacco,

Individuals with diabetes (fasting blood glucose \>125 mg/dL),

hypertension \>160/95 mmHg

Individuals with congestive heart failure, angina, or peripheral vascular disease. --Individuals with ECG evidence of serious arrhythmias and/or acute myocardial ischemia reflected in ST-segment depression of 1 mm or greater at rest or during exercise.

Individuals with chronic infections, paralysis due to stroke, advanced Parkinson's Disease, severe rheumatoid arthritis or other serious orthopedic problems that would prevent performance of the exercise training tasks will be excluded.

Individuals taking antioxidant, herbal or vitamin supplementation for at least 2 weeks prior to investigation.

Individuals ingesting caffeine the day of the experiment.

Individuals whose weight changes by more than 5% during the training program.

Individuals whose exercise adherence is below 90% of the exercise sessions or total exercise time.

What this trial measures

Reactive oxygen species (ROS)change from week 0 to week 8
reactive oxygen species as indicated by H2O2 concentration measured with microdialysis

Trialytics