Understanding Immune Responses in Alcoholic Hepatitis
This observational study aims to understand how the body's immune cells, specifically Peripheral Blood Mononuclear Cells (PBMCs), respond in people with alcoholic hepatitis, heavy drinkers without liver disease, and healthy individuals. Researchers will collect a 50-milliliter blood sample from participants to measure mitochondrial respiration (how cells produce energy). This will help them compare these responses across the different groups. You may be eligible if you are between 21 and 65 years old and have been diagnosed with alcoholic hepatitis, or if you are a heavy drinker without liver disease, or a healthy control. The study plans to enroll 30 participants.
- Study design
- This is an observational study with an unclear status, planning to enroll 30 participants.
- What's involved
- You would have a single blood draw of 50 milliliters.
- Compensation
- Not stated in the trial record.
- Follow-up
- Mitochondrial respiration will be measured at 1 day after the blood draw.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Do you actually qualify for this trial?
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Exclusion
What this trial measures
- Quantify mitochondrial respiration1 day
Mitochondrial Respiration will be quantified by using a standard substrate, uncoupler, inhibitor titration protocol using high resolution respirometry