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NCT04095026

Study of Direct Brain Recording and Stimulation for Memory Enhancement

Enrolling by Invitation
Not specifiedAges 18–65Observational
National Institute of Neurological Disorders and Stroke (NINDS)
~200 participants
Updated 2026-06-01 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
to identify biomarkers of successful memory encoding and retrieval
Measured over during visits/hospitalizations for 11-N-0051
+1 more outcome measured

Conditions

Epilepsy

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Seizure Disorder

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Kareem A Zaghloul, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Neurological Disorders and Stroke (NINDS)

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Be enrolled in 11-N-0051 Epilepsy Surgery.
Able to give informed consent.
Age greater than or equal to 18 years and less than or equal to 65 years

Exclusion

Have any disability that would limit their ability to perform study tasks that examine memory function.

What this trial measures

  • to identify biomarkers of successful memory encoding and retrievalduring visits/hospitalizations for 11-N-0051

    We will compare brain recordings during memory encoding for items that are later recalled versus items that are not later recalled. For example, broadband oscillatory activity from electrodes in human temporal lobe has been shown to predict which items are later recalled

  • to identify brain regions that can be stimulated to enhance memory performanceduring visits/hospitalizations for 11-N-0051

    We will correlate task performance across a variety of memory tasks and electrode locations with stimulation parameters (e.g. frequency and amplitude), to identify those brain areas and stimulation parameters that increase task performance.