TRANSPIRE: Lung Injury in Pediatric HSCT Patients

This study is looking at lung problems that can happen in children and young adults after a hematopoietic stem cell transplant (HSCT). These problems can include diffuse alveolar hemorrhage (DAH), thrombotic microangiopathy (TMA), interstitial pneumonitis (IPS), and bronchiolitis obliterans. The study aims to understand how often these lung injuries occur. We need to learn more about these complications to improve diagnosis and treatment. You may be able to join if you are 24 years old or younger and are having an allogeneic or autologous HSCT. The main goal is to see how many people develop lung injury within 24 months after their transplant. The study plans to enroll 2000 participants, but its current status is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information without giving any specific treatments. It plans to include 2000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will track the incidence of lung injury for 24 months after the HSCT.

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NCT04098445

TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

Recruiting
Not specifiedUp to 24Observational
Children's Hospital Medical Center, Cincinnati
~2,000 participants
Updated 2026-06-22 on ClinicalTrials.gov

At a glance

Recruiting sites
9 of 9 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Lung Injury after HSCT
Measured over 24 months after HSCT
Hematopoietic Stem Cell Transplant (HSCT)
Diffuse Alveolar Hemorrhage
Thrombotic Microangiopathies
Interstitial Pneumonitis
Bronchiolitis Obliterans
9 sites across 8 states
Washington2
California1
Colorado1
Massachusetts1
Minnesota1
Ohio1
Pennsylvania1
Texas1
  • Stella Davies, MBBS, PhD, MRCP · PRINCIPAL_INVESTIGATOR · Children's Hospital Medical Center, Cincinnati

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Eligibility criteria

Inclusion

Subjects ≤ 24 years of age undergoing allogeneic or autologous HSCT.

Exclusion

Subjects over 24 years of age.
  • Incidence of Lung Injury after HSCT24 months after HSCT

    Participants will be assessed for lung injury at 24 months after HSCT