MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics for Hydrocephalus and Alzheimer's Disease

This study is testing a special type of MRI (Magnetic Resonance Imaging) to measure how cerebrospinal fluid (CSF), the fluid around your brain, moves. Researchers want to see if this MR imaging method can help diagnose and better understand conditions like hydrocephalus and Alzheimer's disease, which affect brain function. They will compare CSF movement in healthy adults to those with these conditions. You would have an MRI scan and potentially a urine pregnancy test if you are a pre-menopausal female. The main goal is to see if this MRI method can accurately measure CSF flow. The study is currently unclear on its recruitment status and plans to enroll 50 participants.

Study design: This interventional study plans to enroll 50 participants, comparing healthy individuals with those who have conditions affecting brain function.
What's involved: You would complete an MRI screening form, potentially a urine pregnancy test, and undergo an MR brain scan lasting about one hour.
Compensation: Not stated in the trial record.
Follow-up: CSF flow will be measured at the time of the MR exam, which is approximately one hour.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics

Recruiting

NAAges 18+InterventionalDiagnostic

Mayo Clinic

~50 participants

Updated 2026-01-06 on ClinicalTrials.gov

What's tested:MRI screening formUrine pregnancy testMR brain

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

CSF flow measurement

Measured over At the time of MR exam, approximately one hour

Conditions

Hydrocephalus

Alzheimer Disease

Where it's being run

1 sites across 1 states

Minnesota1

Study leadership

Petrice Cogswell, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Suson (Sue) Walsh

[email protected]

507-293-0039

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

A healthy control will be defined as an otherwise healthy person who does not have a medical condition that affects brain function or have problems with concentration, memory, balance, or coordination.

Patients who have a suspected diagnosis of altered CSF dynamics including but not limited to normal pressure hydrocephalus will be referred to Dr. Cogswell by their care team to be included in the study. Conditions of altered CSF dynamics include obstructive and non-obstructive hydrocephalus and may be associated with headaches and/or decreased cognitive function.

Similarly, patients with impaired cognitive function including but not limited to Alzheimer's disease will be referred to Dr. Cogswell by their care team to be included in the study.

Exclusion

Subjects with non-MRI compatible devices

required sedation

women who may be pregnant will be excluded.

The first 10 subjects with normal pressure hydrocephalus will not have previously been shunted.

What this trial measures

CSF flow measurementAt the time of MR exam, approximately one hour
CSF flow will be measured in participants and compared between those with unimpaired brain function and those with clinical diagnosis of a disease that affects brain function, such as Alzheimer's disease and normal pressure hydrocephalus.

Trialytics