Dietary Potassium and Vascular Health Study

This study is looking at how different levels of potassium and sodium in your diet affect your blood vessels. Researchers want to understand if dietary potassium can protect your blood vessels, especially when you eat a high-sodium diet. You would follow one of three diets for 10 days: Moderate Potassium/Low Sodium, Moderate Potassium/High Sodium, or High Potassium/High Sodium. The study will measure how well your blood vessels expand (conduit artery endothelial-dependent dilation) and how well tiny blood vessels work (microvascular function) after each diet. They are looking for healthy adults between 18 and 45 years old with normal blood pressure and heart readings. The current status of this study is unclear.

Study design
This interventional study plans to enroll 90 healthy participants. It is not specified if the study is randomized or blinded.
What's involved
You would consume specific diets for 10 days. Measurements of your blood vessel function would be taken on day 10 of each diet period.
Compensation
Not stated in the trial record.
Follow-up
Measurements are taken on day 10 of the diet, but no further follow-up is specified.

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NCT04101188

Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans

Recruiting
NAAges 18–45InterventionalPrevention
University of Delaware
~90 participants
Updated 2026-03-04 on ClinicalTrials.gov
What's tested:Moderate Potassium/Low Sodium DietModerate Potassium/High Sodium DietHigh Potassium/High Sodium Diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Conduit artery endothelial-dependent dilation
Measured over on day 10 of the diet
+1 more outcome measured
Cardiovascular Risk Factor
1 sites across 1 states
Delaware1
  • Shannon L Lennon, PhD · PRINCIPAL_INVESTIGATOR · University of Delaware

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Eligibility criteria

Inclusion

healthy
normal blood pressure
normal resting ECG

Exclusion

hypertension
history of heart disease
diabetes
kidney disease
obese (BMI ≥30)
significant weight changes in the last 6 months
use of tobacco products
pregnant
on a special diet (gluten free; vegan)
take any medications for the above conditions
endurance trained athletes
  • Conduit artery endothelial-dependent dilationon day 10 of the diet

    The change in flow-mediated dilation (FMD) between the 3 diets as assessed by brachial artery FMD

  • Microvascular functionon day 10 of the diet

    Cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with intradermal microdialysis