Pregnancy and Developmental Outcomes After Transfer of Aneuploid or Mosaic Embryos

This study is looking at what happens when embryos that are thought to be abnormal (aneuploid or mosaic) are transferred during in vitro fertilization (IVF). Researchers want to see how often these transfers lead to a live birth. They also want to find out if pregnancies from these embryos have more complications, and if the babies born have a higher chance of health or developmental problems in their first five years. You might be able to join if you are a woman between 18 and 55 years old, have aneuploid or mosaic embryos available, and no other acceptable embryos. You also need to be willing to travel to Stanford for treatment and be fluent in English. The study will measure the pregnancy rate over 3 years to see how successful these transfers are.

Study design
This is an interventional study planning to enroll 300 women. It compares outcomes from transferring non-euploid (abnormal) embryos to standard euploid (normal) embryo transfers.
What's involved
You would agree to provide medical records of your pregnancy. For live births, pediatric records and surveys for developmental milestones will be collected for up to 5 years.
Compensation
There is no financial compensation for study participants.
Follow-up
Participants with live births will have their pediatric records and developmental milestones tracked for up to 5 years after birth.

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NCT04109846

Pregnancy and Developmental Outcomes After Transfer of Reportedly Aneuploid or Mosaic Embryos

Recruiting
NAAges 18–55InterventionalTreatment
Stanford University
~300 participants
Updated 2026-04-24 on ClinicalTrials.gov
What's tested:Non-euploid embryo transferEuploid Transfer

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pregnancy Rate
Measured over 3 years
Aneuploidy
Mosaicism
Pregnancy Outcome

NCT04109846

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Stanford Fertility and Reproductive Medicine Center

    Sunnyvale, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Ruth Lathi, MD · PRINCIPAL_INVESTIGATOR · Stanford University

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Eligibility criteria

Inclusion

Available aneuploid or mosaic embryos
No other acceptable embryos available
Willing to travel to Stanford for treatment
English language fluency

Exclusion

Use of international donor eggs or sperm not tested according to FDA guidelines.
Living outside the United States
Embryos with Triploidy are not eligible for transfer in this protocol
  • Pregnancy Rate3 years

    Number participants who undergo embryo transfers that lead to a positive pregnancy test