Managing Pain After Hysterectomy with Intraperitoneal Infusion
This study is looking at ways to reduce pain and the need for strong pain medications (narcotics) after a hysterectomy (surgery to remove the uterus). You might be eligible if you are a woman between 18 and 65 years old, planning a minimally invasive hysterectomy for a non-cancerous reason like fibroids or endometriosis. The study will compare three different treatments given directly into the abdomen (intraperitoneal) using a special pump for 72 hours after surgery: ropivacaine, a combination of ropivacaine and ketorolac (an anti-inflammatory drug), or a saline solution (placebo). Researchers will measure your pain levels at 1, 2, and 4 hours after surgery to see if these treatments are effective. The study aims to find out if these infusions can significantly lower your pain and narcotic use.
- Study design
- This is a prospective, double-blinded, placebo-controlled study involving 120 participants. Participants will be randomly assigned to one of three treatment groups.
- What's involved
- You will complete a health-related quality of life questionnaire before surgery. After surgery, you will receive an infusion for 72 hours, and your pain levels will be measured at 1, 2, and 4 hours post-operation.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your pain levels will be measured at 1, 2, and 4 hours after surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Intraperitoneal Infusion of Analgesic for Postoperative Pain Management
At a glance
Conditions
NCT04130464
Where you'd take part
This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
MedStar Washington Hospital Center
Washington D.C., District of Columbiastudy coordinator listed
Recruiting
The GW Medical Faculty Associates
Washington D.C., District of Columbiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jennifer Keller, MD · PRINCIPAL_INVESTIGATOR · Physician
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Pain Level 1 Hour Postoperative1 hour postoperative
Rating from 0 "No pain sensation" to 10 "most intense pain imaginable"
- Pain Level 2 Hours Postoperative2 hours postoperative
Rating from 0 "No pain sensation" to 10 "most intense pain imaginable"
- Pain Level 4 Hours Postoperative4 hours postoperative
Rating from 0 "No pain sensation" to 10 "most intense pain imaginable"
- Pain Level 6 Hours Postoperative6 hours postoperative
Rating from 0 "No pain sensation" to 10 "most intense pain imaginable"
- Pain Level 24 Hours Postoperative24 hours postoperative
Rating from 0 "No pain sensation" to 10 "most intense pain imaginable"
- Pain Level 48 Hours Postoperative48 hours postoperative
Rating from 0 "No pain sensation" to 10 "most intense pain imaginable"
- Pain Level 72 Hours Postoperative72 hours postoperative
Rating from 0 "No pain sensation" to 10 "most intense pain imaginable"