Carbon Dioxide (CO2) Chemosensitivity and SUDEP
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Brian Gehlbach, MD · PRINCIPAL_INVESTIGATOR · University of Iowa
- George Richerson, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Iowa
Who to contact
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What this trial measures
- Determine the correlation between baseline central CO2 chemosensitivity and the increase in transcutaneous CO2 levels after a seizure.Immediately before and after a seizure, variable for each subject but approximately 10 minutes
The change in HCVR slope (change in minute ventilation \[liters/min\] vs change in end tidal CO2 \[mm Hg\]) will be correlated with the increase in transcutaneous CO2 level (mm Hg) provoked by a seizure.
- Determine the correlation between baseline central CO2 chemosensitivity and the duration of transcutaneous CO2 elevation above baseline after a seizure.Duration of hospital admission, approximately 5 days
The change in HCVR slope (change in minute ventilation \[liters/min\] vs change in end tidal CO2 \[mm Hg\]) will be correlated with the duration (minutes) of end tidal CO2 elevation above pre-seizure baseline
- Effect of seizures on HCVR slope (liters/min/mm Hg)Up to 18 hours after a seizure.
The percent change in HCVR slope (liters/min/mm Hg) from baseline that is induced by a seizure will be measured. The HCVR will be administered at 30 minutes, 2 hours, and 18 hours after nonconvulsive seizures. The HCVR will be administered at 2 hours and 18 hours after convulsive seizures.
- Determine the stability of the HCVR slope over time in patients with epilepsy. of the HCVR over time in patients with epilepsy2 years
The stability of the HCVR slope (liters/min/mm Hg) measured 8 months for 2 years will be assessed using a generalized linear mixed model.