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Skeletal Muscle Energetics and Fatiguability in Older Individuals

This observational study is looking at how the energy use in leg muscles (skeletal muscle energetics) and how easily they get tired (fatiguability) are connected to exercise ability in older adults. Researchers want to understand why some older people living with HIV experience more fatigue and difficulty exercising compared to older people without HIV. They will use non-invasive MRI and MRS scans of the leg muscle, along with blood samples, to measure muscle health and inflammation. The study aims to see if differences in muscle energy use are linked to how well people can exercise, measured by things like how far you can walk in six minutes. This study is currently recruiting 200 participants, aged 60 to 90, including those with HIV on stable treatment and those without HIV.

Study design
This is an observational study planning to enroll 200 participants. It is not testing a specific drug or intervention.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Primary endpoints are measured at Baseline, so there is no specified follow-up period after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT04142047

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Recruiting
Not specifiedAges 60–90Observational
Johns Hopkins University
~200 participants
Updated 2026-06-08 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Maximal mitochondrial oxidative capacity (VmaxPCr)
Measured over Baseline
+2 more outcomes measured

Conditions

HIV
HIV Infections

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HIV InfectionHIV Infection

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Robert G Weiss, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Maria Esteban, RN, BSN
[email protected]
410-955-1160
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participants who are \>= 60 years of age
HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies).
HIV serostatus negative participants

Exclusion

Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
Contraindications to MRI
Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
Significant lower extremity peripheral vascular disease.
Weight greater than 350 lbs
Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.

What this trial measures

  • Maximal mitochondrial oxidative capacity (VmaxPCr)Baseline

    Maximal oxidative capacity of leg muscle measured by 31P Magnetic Resonance Spectroscopy (MRS)

  • Rate of PCr decline during plantar flexion exerciseBaseline
  • Six minute walk distanceBaseline